DNA Replication and Cancer

This lecture delves into the relationship between DNA replication and cancer, explaining how mutations in key genes involved in DNA repair can lead to the development of various types of cancers. The instructor discusses the importance of DNA repair mechanisms in maintaining genetic stability and how different factors, such as UV radiation and chemical mutagens, can induce DNA damage. The lecture also covers the process of nucleotide excision repair (NER) and its role in correcting DNA lesions, highlighting specific genetic diseases like xeroderma pigmentosum associated with mutations in NER genes. By exploring the intricate mechanisms of DNA repair, the lecture provides insights into the molecular basis of cancer development.