Retinoblastoma: Genetic Mechanisms and Clinical Implications

This lecture delves into the genetic mechanisms underlying retinoblastoma, a rare eye cancer that develops in children. The instructor explains the role of the RB gene in tumor suppression, the importance of DNA repair and apoptosis in preventing cancer, and the significance of mutations in the development of retinoblastoma. Through a detailed analysis of genetic recombination and crossing over, the lecture explores how these processes contribute to the formation of tumors. The discussion extends to twin spots in Drosophila melanogaster, providing insights into genetic inheritance and phenotypic expression. The lecture concludes with a comparison between retinoblastoma and skin color genetics, emphasizing the complex interplay between genetic mutations and cancer development.