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This lecture covers the physiology of blood flow, pressure, and regulation in the cardiovascular system. Topics include the relationship between blood pressure and flow, the role of vascular resistance and compliance, the mechanisms of arterial pulse, the distribution of cardiac output, and the regulation of blood flow in different organs. The lecture also discusses the principles of the Frank-Starling law, the intrinsic regulation of heart contractility, the pressure-volume relationship in the heart, and the electrical excitation of the heart. Various experimental examples and physiological concepts are presented to explain the intricate mechanisms governing cardiovascular function.