Glycerophospholipid Synthesis

This lecture covers the synthesis of glycerophospholipids, starting from glycolysis to the formation of phosphatidic acid and its conversion into both triglycerides and phospholipids. The process involves the esterification of acyl chains, addition of head groups, and head group remodelling. Different strategies for adding head groups to phosphatidic acid are discussed, along with the synthesis of phosphatidylserine, phosphatidylethanolamine, phosphatidylcholine, and cardiolipin. The lecture also explains the synthesis of cholesterol from acetate, involving mevalonate and isoprene units. Key enzymes and reactions in the pathways are highlighted.

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