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Like a variety of other pathogenic bacteria, Aeromonas hydrophila secretes a pore-forming toxin that contribute to its virulence. The last decade has not only increased our knowledge about the structure of this toxin, called aerolysin, but has also shed light on how it interacts with its target cell and how the cell reacts to this stress. Whereas pore-forming toxins are generally thought to lead to brutal death by osmotic lysis of the cell, based on what is observed for erythrocytes, recent studies have started to reveal far more complicated pathways leading to death of nucleated mammalian cells.
Anja Skrivervik, Zvonimir Sipus, Mingxiang Gao
Vincent Kaufmann, Daniel Gatica-Perez, Claudia Rebeca Binder Signer, Anna Pagani, Garance Clément, Livia Bianca Fritz, Laurie Daffe, Melissa Pang, Ulrike Vilsmaier