Publication

On-chip thermopneumatic actuation system for coagulation time measurement

Abstract

This work reports the demonstration of a thermopneumatic microfluidic actuator used to determine blood coagulation time. In this new system, the detection principle is the obstruction of a microfluidic channel by clotted blood. The sample actuation is done by aspiration due to air cooling in a cavity. We made a study of the position of the blood plug depending on the presence in the channel of coagulation reagent and observe a slowdown of the plug on a coated channel compared to a blank one.

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Related concepts (32)
Coagulation
Coagulation, also known as clotting, is the process by which blood changes from a liquid to a gel, forming a blood clot. It potentially results in hemostasis, the cessation of blood loss from a damaged vessel, followed by repair. The mechanism of coagulation involves activation, adhesion and aggregation of platelets, as well as deposition and maturation of fibrin. Coagulation begins almost instantly after an injury to the endothelium lining a blood vessel.
Air cooling
Air cooling is a method of dissipating heat. It works by expanding the surface area or increasing the flow of air over the object to be cooled, or both. An example of the former is to add cooling fins to the surface of the object, either by making them integral or by attaching them tightly to the object's surface (to ensure efficient heat transfer). In the case of the latter, it is done by using a fan blowing air into or onto the object one wants to cool.
Anticoagulant
Anticoagulants, commonly known as blood thinners, are chemical substances that prevent or reduce coagulation of blood, prolonging the clotting time. Some of them occur naturally in blood-eating animals such as leeches and mosquitoes, where they help keep the bite area unclotted long enough for the animal to obtain some blood. As a class of medications, anticoagulants are used in therapy for thrombotic disorders. Oral anticoagulants (OACs) are taken by many people in pill or tablet form, and various intravenous anticoagulant dosage forms are used in hospitals.
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