Publication

Asymmetric synthesis. XXII. Formal synthesis of (-)-perhydrohistrionicotoxin

Jieping Zhu
1991
Journal paper

Abstract

The synthesis of (-)-depentylperhydrohistrionicotoxin (I, R = H) from the 2-cyano-6-oxazolopiperidine synthon (-)-II was achieved. The spiro skeleton was formed by an aldol cyclization of a Me ketone and an aldehyde function belonging to chains borne at C-2. Since the transformation of (+-)-I (R = H) into (+-)-perhydrohistrionicotoxin (I, R = pentyl) is known, the synthesis of (-)-I (R = H) represents a formal synthesis of (-)-perhydrohistrionicotoxin. [on SciFinder (R)]

Official source

https://infoscience.epfl.ch/record/158216?ln=en

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Asymmetric synthesis. XXII. Formal synthesis of (-)-perhydrohistrionicotoxin

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