Publication

Phage selection of cyclic peptide antagonists with increased stability toward intestinal proteases

Christian Heinis, Vanessa Baeriswyl
2013
Journal paper

Abstract

The oral delivery of protein and peptide drugs is limited by their proteolytic degradation and the poor absorption across the intestinal epithelia. In this work, we exposed a phage library of small bicyclic peptides (

Official source

https://infoscience.epfl.ch/record/182745?ln=en

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Phage selection of cyclic peptide antagonists with increased stability toward intestinal proteases

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Towards the Development of Orally Available Peptide Therapeutics

De novo development of proteolytically resistant therapeutic peptides for oral administration

Structure and Function of the T4 Spackle Protein Gp61.3

Towards the Development of Orally Available Peptide Therapeutics

Structure and Function of the T4 Spackle Protein Gp61.3

De novo development of proteolytically resistant therapeutic peptides for oral administration