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It is well known that spherical D-branes are nucleated in the presence of an external RR electric field. Using the description of D-branes as solitons of the tachyon field on non-BPS D-branes, we show that the brane nucleation process can be seen as the decay of the tachyon false vacuum. This process can describe the decay of flux-branes in string theory or the decay of quintessence potentials arising in flux compactifications.