Publication

Adaptation and Optimization of an Intraneural Electrode to Interface with the Cervical Vagus Nerve

Silvestro Micera, Ivo Strauss
2021
Conference paper
Abstract

The modulation of the cervical vagus nerve (VN) using neural electrodes has shown great potential to treat cardiovascular, inflammatory, intestinal, or respiratory dysfunctions. Intraneural electrodes have shown great potentials for other neuroprosthetic applications. Therefore, their use for VN modulation could have great potential. Here we optimized an intraneural electrode originally developed for use in lower limb amputees. Based on histological data from the VN of 100 histological sections we adapted and optimized the dimensions of the Quick-to-implant peripheral neural electrode (Q-PINE). Parts of the Q- PINE were substituted to increase biocompatibility. The platinum-iridium (Pt/Ir) wires were substituted with a polyimide thin-film structure to optimize the electrodes' impedance. Mechanical and electrochemical characterization was performed to exclude negative alterations resulting from the design and material changes. The dimensional adaptation and material substitutions of the Q- PINE did not alter its mechanical or electrochemical properties. The tfQPINE shows promising results for the successful application with the VN.

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Related concepts (32)
Neuroprosthetics
Neuroprosthetics (also called neural prosthetics) is a discipline related to neuroscience and biomedical engineering concerned with developing neural prostheses. They are sometimes contrasted with a brain–computer interface, which connects the brain to a computer rather than a device meant to replace missing biological functionality. Neural prostheses are a series of devices that can substitute a motor, sensory or cognitive modality that might have been damaged as a result of an injury or a disease.
Osmiridium
Osmiridium and iridosmine are natural alloys of the elements osmium and iridium, with traces of other platinum-group metals. Osmiridium has been defined as containing a higher proportion of iridium, with iridosmine containing more osmium. However, as the content of the natural Os-Ir alloys varies considerably, the constituent percentages of specimens often reflects the reverse situation of osmiridium describing specimens containing a higher proportion of osmium and iridosmine specimens containing more iridium.
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