The sequential condensation of peptide loops onto selectively addressable templates immobilised on solid supports allows the rapid and efficient synthesis of protein mimetics applying the TASP (Template Assembled Synthetic Protein) concept. As an example of the versatility of this methodology, we describe here the solid phase assembly of a representative 3-loop receptor mimetic. (C) 1997 Elsevier Science Ltd.
Kevin Sivula, Nestor Guijarro Carratala, Xavier Adrian Jeanbourquin, Xiaoyun Yu, Andrea Gasperini, Emilie Aude Marie Ripaud