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The Laboratory of Synthesis and Inorganic Catalysis at EPFL focuses on developing catalysts made of Earth-abundant elements for chemical transformations related to synthesis, energy, and sustainability. Research areas include base metal catalyzed organic synthesis, artificial enzymes, biocatalysis, electrochemical water splitting, and CO2 reduction. The lab's interdisciplinary research involves organic synthesis, homogeneous catalysis, bio-inorganic chemistry, and electrochemistry. Projects include developing well-defined Ni-based coordination complexes for organic synthesis and bio-inspired H2 activation. Recent achievements include publications on sustained pure-water electrolysis, smart chemistry for anticancer therapeutics, and tailored water transport in membrane electrode assembly electrolyzers.