Unit
Prof. Constam Group
LaboratorySummary
The Constam lab at EPFL focuses on Developmental and Cancer Cell Biology, using genetic and biochemical approaches to study molecular mechanisms in cell and tissue growth and differentiation. Research projects include investigating TGFb signaling in development and cancer, live imaging of proprotein convertases, and the regulation of mRNA translation and cell metabolism in polycystic kidney diseases. A key area of interest is understanding how factors like the RNA-binding protein Bicc1 and specific interacting factors impact cancer progression and metastasis by regulating various signaling pathways.
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Related publications (67)
New roles of Bicc1 in cilia formation, cell adhesion, and in adult kidneys.
Bicaudal-C1 (Bicc1), an RNA-Binding protein, is a ciliopathy-associated protein. In development, Bicc1 is necessary for left-right axis specification. Loss of Bicc1 in mice also associates with polycystic kidney development. In human, two hereditary polycy ...
EPFL2023Multimodal characterization of murine gastruloid development
Matthias Lütolf, Alexandre Gauthier Aurèle Mayran, Stefano Davide Vianello, Raphaël Ortiz
Gastruloids are 3D structures generated from pluripotent stem cells recapitulating fundamental principles of embryonic pattern formation. Using single-cell genomic analysis, we provide a resource mapping cell states and types during gastruloid development ...
CELL PRESS2023In vitro endoderm emergence and self-organisation in the absence of extraembryonic tissues and embryonic architecture
In humans, mice, and other mammals key internal organs such as the gut, the lungs, the pancreas, and the liver all derive from the same embryonic tissue: the endoderm. The development of all of these structures thus depends on a same set of early cells, an ...
EPFL2022