Laser radiation safety is the safe design, use and implementation of lasers to minimize the risk of laser accidents, especially those involving eye injuries. Since even relatively small amounts of laser light can lead to permanent eye injuries, the sale and usage of lasers is typically subject to government regulations. Moderate and high-power lasers are potentially hazardous because they can burn the retina, or even the skin. To control the risk of injury, various specifications, for example 21 Code of Federal Regulations (CFR) Part 1040 in the US and IEC 60825 internationally, define "classes" of laser depending on their power and wavelength. These regulations impose upon manufacturers required safety measures, such as labeling lasers with specific warnings, and wearing laser safety goggles when operating lasers. Consensus standards, such as American National Standards Institute (ANSI) Z136, provide users with control measures for laser hazards, as well as various tables helpful in calculating maximum permissible exposure (MPE) limits and accessible exposures limits (AELs). Thermal effects are the predominant cause of laser radiation injury, but photo-chemical effects can also be of concern for specific wavelengths of laser radiation. Even moderately powered lasers can cause injury to the eye. High power lasers can also burn the skin. Some lasers are so powerful that even the diffuse reflection from a surface can be hazardous to the eye. The coherence and low divergence angle of laser light, aided by focusing from the lens of an eye, can cause laser radiation to be concentrated into an extremely small spot on the retina. A transient increase of only +10°C (+18°F) can destroy retinal photoreceptor cells. If the laser is sufficiently powerful, permanent damage can occur within a fraction of a second, which is faster than the blink of an eye. Sufficiently powerful lasers in the visible to near infrared range (400-1400 nm) will penetrate the eyeball and may cause heating of the retina, whereas exposure to laser radiation with wavelengths less than 400 nm or greater than 1400 nm are largely absorbed by the cornea and lens, leading to the development of cataracts or burn injuries.

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