Esophagectomy or oesophagectomy is the surgical removal of all or parts of the esophagus. The principal objective is to remove the esophagus, a part of the gastrointestinal tract. This procedure is usually done for patients with esophageal cancer. It is normally done when esophageal cancer is detected early, before it has spread to other parts of the body. Esophagectomy of early-stage cancer represents the best chance of a cure. Despite significant improvements in technique and postoperative care, the long-term survival for esophageal cancer is still poor. Multimodality treatment (chemotherapy and radiation therapy) is needed for advanced tumors. Esophagectomy is also occasionally performed for benign disease such as esophageal atresia in children, achalasia, or caustic injury. In those who have had an esophagectomy for cancer, omentoplasty (a procedure in which part of the greater omentum is used to cover or fill a defect, augment arterial or portal venous circulation, absorb effusions, or increase lymphatic drainage) appears to improve outcomes. There are two main types of esophagectomy. A transhiatal esophagectomy (THE) is performed on the neck and abdomen simultaneously. A transthoracic esophagectomy (TTE) involves opening the thorax (chest). In most cases, the stomach is transplanted into the neck and the stomach takes the place originally occupied by the esophagus. In some cases, the removed esophagus is replaced by another hollow structure, such as the patient's colon. Another option that is slowly becoming available is minimally invasive surgery (MIS) which is performed laparoscopically and thoracoscopically. After surgery, patients may have trouble with a regular diet and may have to consume softer foods, avoid liquids at meals, and stay upright for 1–3 hours after eating. Dysphagia is common and patients are encouraged to chew foods very well or grind their food. Patients may complain of substernal pain that resolves by sipping fluids or regurgitating food.

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