Category
Neurotransmission
Related publications (1,000)
Impact of Mitofusin 2 in the Nucleus Accumbens on motivated behavior and underlying neurobiological mechanisms
The nucleus accumbens (NAc) is part of the ventral striatum and plays a major role in motivation and goal-directed behaviour. Increasing evidence implicates impairments in accumbal function in anxiety and depression, two conditions that are commonly accomp ...
EPFL2024A bistable inhibitory optoGPCR for multiplexed optogenetic control of neural circuits
Information is transmitted between brain regions through the release of neurotransmitters from long-range projecting axons. Understanding how the activity of such long-range connections contributes to behavior requires efficient methods for reversibly mani ...
Nature Portfolio2024White adipose tissue distribution and amount are associated with increased white matter connectivity
Jean-Philippe Thiran, Gabriel Girard, Elda Fischi Gomez, Philipp Johannes Koch, Liana Okudzhava
Obesity represents a significant public health concern and is linked to various comorbidities and cognitive impairments. Previous research indicates that elevated body mass index (BMI) is associated with structural changes in white matter (WM). However, a ...
Hoboken2024Unveiling the complexity of learning and decision-making
Reinforcement learning (RL) is crucial for learning to adapt to new environments. In RL, the prediction error is an important component that compares the expected and actual rewards. Dopamine plays a critical role in encoding these prediction errors. In my ...
EPFL2024Non-invasive stimulation of the human striatum disrupts reinforcement learning of motor skills
Friedhelm Christoph Hummel, Takuya Morishita, Pierre Theopistos Vassiliadis, Elena Beanato, Esra Neufeld, Fabienne Windel, Maximilian Jonas Wessel, Traian Popa, Julie Duqué
Reinforcement feedback can improve motor learning, but the underlying brain mechanisms remain underexplored. In particular, the causal contribution of specific patterns of oscillatory activity within the human striatum is unknown. To address this question, ...
Nature Portfolio2024Fear learning induces synaptic potentiation between engram neurons in the rat lateral amygdala
Henry Markram, Rodrigo de Campos Perin
The lateral amygdala (LA) encodes fear memories by potentiating sensory inputs associated with threats and, in the process, recruits 10-30% of its neurons per fear memory engram. However, how the local network within the LA processes this information and w ...
Nature Portfolio2024Subcortical correlates of consciousness with human single neuron recordings
Olaf Blanke, Fosco Bernasconi, Nathan Quentin Faivre, Michael Eric Anthony Pereira
Subcortical brain structures such as the basal ganglia or the thalamus are involved in regulating motor and cognitive behavior. However, their contribution to perceptual consciousness is still unclear, due to the inherent difficulties of recording subcorti ...
2024Involvement of prelimbic cortex neurons and related circuits in the acquisition of a cooperative learning by pairs of rats
Maria del Carmen Sandi Perez, Elias Georges Gebara, Ana del Rocio Conde Moro
Social behaviors such as cooperation are crucial for mammals. A deeper knowledge of the neuronal mechanisms underlying cooperation can be beneficial for people suffering from pathologies with impaired social behavior. Our aim was to study the brain activit ...
Springer2024Structural heterogeneity of the ion and lipid channel TMEM16F
Transmembrane protein 16 F (TMEM16F) is a Ca2+-activated homodimer which functions as an ion channel and a phospholipid scramblase. Despite the availability of several TMEM16F cryogenic electron microscopy (cryo-EM) structures, the mechanism of activation ...
Berlin2024An integrated heart-torso electromechanical model for the simulation of electrophysiological outputs accounting for myocardial deformation
Alfio Quarteroni, Francesco Regazzoni
When generating in-silico clinical electrophysiological outputs, such as electrocardiograms (ECGs) and body surface potential maps (BSPMs), mathematical models have relied on single physics, i.e. of the cardiac electrophysiology (EP), neglecting the role o ...
Elsevier Science Sa2024