Publications related to Proteinopathy

AFM-Based Single Molecule Techniques: Unraveling the Amyloid Pathogenic Species

Giovanni Dietler, Francesco Simone Ruggeri, Andrea Cerreta

Background: A wide class of human diseases and neurodegenerative disorders, such as Alzheimer's disease, is due to the failure of a specific peptide or protein to keep its native functional conformational state and to undergo a conformational change into a ...

Bentham Science Publishers2016

A critical concentration of N-terminal pyroglutamylated amyloid beta drives the misfolding of Ab1-42 into more toxic aggregates

Giovanni Dietler, Francesco Simone Ruggeri

A wide consensus based on robust experimental evidence indicates pyroglutamylated amyloid-beta isoform (A beta pE3-42) as one of the most neurotoxic peptides involved in the onset of Alzheimer's disease. Furthermore, A beta pE3-42 co-oligomerized with exce ...

Elsevier2016

Nanoscale studies link amyloid maturity with polyglutamine diseases onset

Giovanni Dietler, Hilal Lashuel, Giovanni Longo, Francesco Simone Ruggeri, Urszula Beata Cendrowska

The presence of expanded poly-glutamine (polyQ) repeats in proteins is directly linked to the pathogenesis of several neurodegenerative diseases, including Huntington's disease. However, the molecular and structural basis underlying the increased toxicity ...

Nature Publishing Group2016

A subcutaneous cellular implant for passive immunization against amyloid-beta reduces brain amyloid and tau pathologies

Patrick Aebischer, Bernard Schneider, Aurélien Lathuilière, Vanessa Laversenne, Marco Stampanoni

Passive immunization against toxic misfolded proteins could offer protection against neurodegenerative disease. LathuiliSre et al. report the development of a retrievable device to encapsulate cells secreting recombinant anti-amyloid-beta antibodies. When ...

Oxford Univ Press2016

Automated longitudinal monitoring of in vivo protein aggregation in neurodegenerative disease C. elegans models

Johan Auwerx, Martinus Gijs, Thomas Lehnert, Matteo Cornaglia, Laurent Mouchiroud, Vincenzo Sorrentino, Govindan Narayanan Krishnamani

Background: While many biological studies can be performed on cell-based systems, the investigation of molecular pathways related to complex human dysfunctions - e.g. neurodegenerative diseases - often requires long-term studies in animal models. The nemat ...

BioMed Central2016

Gastro-intestinal biomarkers for diagnosis and therapies of proteinopathies

Theo Lasser, Tristan Bolmont, Taoufiq Harach

Pharmaceutical composition for the treatment of proteinopathies comprising products which are able to stimulate growth or inhibition of at least one of Odoribacter, Oscillospira, Dehalobacterium, Alistipes, Parabacteroides, Lactobacillus and Sutterella, Fi ...

2016

Experimental Milestones in the Discovery of Molecular Chaperones as Polypeptide Unfolding Enzymes

Pierre Goloubinoff, Andrija Finka

Molecular chaperones control the cellular folding, assembly, unfolding, disassembly, translocation, activation, inactivation, disaggregation, and degradation of proteins. In 1989, groundbreaking experiments demonstrated that a purified chaperone can bind a ...

Annual Reviews2016

Induction of de novo α-synuclein fibrillization in a neuronal model for Parkinson's disease

Hilal Lashuel, Bohumil Maco, Abid Oueslati, Mohamed Bilal Fares

Lewy bodies (LBs) are intraneuronal inclusions consisting primarily of fibrillized human α-synuclein (hα-Syn) protein, which represent the major pathological hallmark of Parkinson's disease (PD). Although doubling hα-Syn expression provokes LB pathology in ...

Natl Acad Sciences2016

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Proteinopathy

AFM-Based Single Molecule Techniques: Unraveling the Amyloid Pathogenic Species

A critical concentration of N-terminal pyroglutamylated amyloid beta drives the misfolding of Ab1-42 into more toxic aggregates

Discriminative adsorption of amphiphilic monolayer protected gold nanoparticles on amyloid fibers

Nanoscale studies link amyloid maturity with polyglutamine diseases onset

A subcutaneous cellular implant for passive immunization against amyloid-beta reduces brain amyloid and tau pathologies

Automated longitudinal monitoring of in vivo protein aggregation in neurodegenerative disease C. elegans models

Gastro-intestinal biomarkers for diagnosis and therapies of proteinopathies

Experimental Milestones in the Discovery of Molecular Chaperones as Polypeptide Unfolding Enzymes

Induction of de novo α-synuclein fibrillization in a neuronal model for Parkinson's disease

Endogenous Regulators of Gamma-Secretase and Amyloid-Beta Production, and Engineering of Alzheimer's Disease Therapeutic Tools

Graph Chatbot

Chat with Graph Search

Discriminative adsorption of amphiphilic monolayer protected gold nanoparticles on amyloid fibers

Experimental Milestones in the Discovery of Molecular Chaperones as Polypeptide Unfolding Enzymes

AFM-Based Single Molecule Techniques: Unraveling the Amyloid Pathogenic Species

A critical concentration of N-terminal pyroglutamylated amyloid beta drives the misfolding of Ab1-42 into more toxic aggregates

Gastro-intestinal biomarkers for diagnosis and therapies of proteinopathies

Nanoscale studies link amyloid maturity with polyglutamine diseases onset

Induction of de novo α-synuclein fibrillization in a neuronal model for Parkinson's disease

Endogenous Regulators of Gamma-Secretase and Amyloid-Beta Production, and Engineering of Alzheimer's Disease Therapeutic Tools

Automated longitudinal monitoring of in vivo protein aggregation in neurodegenerative disease C. elegans models

A subcutaneous cellular implant for passive immunization against amyloid-beta reduces brain amyloid and tau pathologies