Concept
Lead compound
Related publications (62)
Improved microfluidic transcriptome based screening methods
Christoph Merten, Xiaoli Ma, Leonie Kolmar, Hongxing Hu
The invention provides microfluidic screening systems for the identification of compounds or compositions influencing cellular transcriptomes. The invention is predicated upon taking into account differences in newly synthesized mRNA in contrast to so call ...
2024High-throughput screening of Weyl semimetals
Nicola Marzari, Davide Campi, Davide Grassano
Topological Weyl semimetals represent a novel class of nontrivial materials, where band crossings with linear dispersions take place at generic momenta across reciprocal space. These crossings give rise to low -energy properties akin to those of Weyl fermi ...
College Pk2024A multi-reservoir extruder for time-resolved serial protein crystallography and compound screening at X-ray free-electron lasers
Christoph Bostedt, Camila Bacellar Cases Da Silveira
Serial crystallography at X-ray free-electron lasers (XFELs) permits the determination of radiation-damage free static as well as time-resolved protein structures at room temperature. Efficient sample delivery is a key factor for such experiments. Here, we ...
Berlin2023Multimodal characterization of murine gastruloid development
Matthias Lütolf, Alexandre Gauthier Aurèle Mayran, Stefano Davide Vianello, Raphaël Ortiz
Gastruloids are 3D structures generated from pluripotent stem cells recapitulating fundamental principles of embryonic pattern formation. Using single-cell genomic analysis, we provide a resource mapping cell states and types during gastruloid development ...
CELL PRESS2023Identification of broad anti-coronavirus chemical agents for repurposing against SARS-CoV-2 and variants of concern
Gerardo Turcatti, Fabien Kuttler, Michael Bauer, Liliane Yang
Endemic human coronaviruses (hCoVs) 229E and OC43 cause respiratory disease with recurrent infections, while severe acute respiratory syndrome (SARS)-CoV-2 spreads across the world with impact on health and societies. Here, we report an image-based multicy ...
2022Photochemical oxidation of phenols and anilines mediated by phenoxyl radicals in aqueous solution
Urs von Gunten, Silvio Canonica, Stephanie Christa Remke
Reactive intermediates formed upon irradiation of chromophoric dissolved organic matter (CDOM) contribute to the degradation of various organic contaminants in surface waters. Besides well-studied "short-lived" photo oxidants, such as triplet state CDOM (3 ...
PERGAMON-ELSEVIER SCIENCE LTD2022Generating macrocyclic inhibitors of protein-protein interactions
Protein-protein interactions (PPIs) play important roles in many diseases and their modulation is an attractive strategy for developing new therapeutics. However, the relatively large and often flat binding surfaces of PPIs makes the development of inhibit ...
EPFL2022NICEdrug.ch, a workflow for rational drug design and systems-level analysis of drug metabolism
Vassily Hatzimanikatis, Jasmin Maria Hafner, Homa Mohammadi Peyhani, Noushin Hadadi, Anush Chiappino-Pepe
The discovery of a drug requires over a decade of intensive research and financial investments – and still has a high risk of failure. To reduce this burden, we developed the NICEdrug.ch resource, which incorporates 250,000 bioactive molecules, and studied ...
2021Discovery of 2-(4-(2-fluoroethoxy)piperidin-1-yl)-9-methyl-9H-pyrrolo[2,3-b:4,5-c']dipyridine ([18F]PI-2014) as PET tracer for the detection of pathological aggregated tau in Alzheimer's disease and other tauopathies
The compound screening was initiated with a direct staining assay to identify compounds binding to Tau aggregates and not Abeta plaques using human brain sections derived from late stage Alzheimer's disease donors. The binding of Tau aggregate selective co ...
ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER2020Probing the interaction of nanoparticles with small molecules in real time via quartz crystal microbalance monitoring
Stefan Guldin, Ye Yang, Nikolaos Nianias, Runzhang Qi
Despite extensive advances in the field of molecular recognition, the real-time monitoring of small molecule binding to nanoparticles (NP) remains a challenge. To this end, we report on a versatile approach, based on quartz crystal microbalance with dissip ...
ROYAL SOC CHEMISTRY2019