Concept

Modelling biological systems

Related publications (59)

Parallel Molecular Dynamics with Irregular Domain Decomposition

The spatial domain of Molecular Dynamics simulations is usually a regular box that be easily divided in subdomains for parallel processing. Recent efforts aimed at simulating complex biological systems, like the blood flow inside arteries, require the exec ...

Cambridge University Press2011

High-Resolution and Tandem Mass Spectrometry – the Indispensable Tools of the XXI Century

Yury Tsybin, Anton Kozhinov, Luca Fornelli, Aleksey Vorobyev, Sasa Miladinovic

Mass spectrometry-based qualitative and quantitative (bio)molecular analysis is a corner stone in the state-of-the-art pipelines in systems biology and environmental sciences. High-resolution and efficient tandem mass spectrometry methods and techniques ar ...

Schweizerische Chemische Gesellschaft2011

Hybrid Numerical Solution of the Chemical Master Equation

Maria-Emanuela-Canini Mateescu, Verena Wolf

We present a numerical approximation technique for the analysis of continuous-time Markov chains that describe networks of biochemical reactions and play an important role in the stochastic modeling of biological systems. Our approach is based on the const ...

2010

Towards a Rigorous Assessment of Systems Biology Models: The DREAM3 Challenges

Daniel Marbach

Background: Systems biology has embraced computational modeling in response to the quantitative nature and increasing scale of contemporary data sets. The onslaught of data is accelerating as molecular profiling technology evolves. The Dialogue for Reverse ...

Public Library of Science2010

Implicit methods for modeling gene regulatory networks

Abhishek Garg

Advancements in high-throughput technologies to measure increasingly complex biological phenomena at the genomic level are rapidly changing the face of biological research from single-gene single-protein experimental approach to studying the behaviour of a ...

EPFL2009

Integration column: Microfluidic high-throughput screening

Sebastian Maerkl

Biology has always been a heavily technology limited field. Burgeoning fields such as systems biology require the development and implementation of new technologies, enabling high-throughput and high-fidelity measurements of large systems. Microfluidics pr ...

2009

Analysis and Design of Biological Circuits and Systems

Systems and synthetic biology are two emerging disciplines that hold promise to revolutionize our understanding of biological systems and to herald a new era of programmable hardware, respectively. Mathematical abstraction and today's abundance of quantita ...

IEEE2009

Fast Adaptive Uniformization for the Chemical Master Equation

Maria-Emanuela-Canini Mateescu, Verena Wolf

Within systems biology there is an increasing interest in the stochastic behavior of biochemical reaction networks. An appropriate stochastic description is provided by the chemical master equation, which represents a continuous-time Markov chain (CTMC). S ...

Ieee Computer Soc Press, Customer Service Center, Po Box 3014, 10662 Los Vaqueros Circle, Los Alamitos, Ca 90720-1264 Usa2009

Stochastic Modeling and Control of Biological Systems: The Lactose Regulation System of Escherichia coli

Mahmut Selman Sakar

In this paper, we present a comprehensive framework for stochastic modeling, model abstraction, and controller design for a biological system. The first half of the paper concerns modeling and model abstraction of the system. Most models in systems biology ...

Institute of Electrical and Electronics Engineers2008

Towards a Scientific Model Management System

Stefano Spaccapietra, José Antonio Fernandes de Macedo

Computational models of biological systems aim at accurately simulating in vivo phenomena. They have become a very powerful tool enabling scientists to study complex behavior. A side effect of their success Unfortunately exists and is observed as an increa ...

Springer-Verlag New York, Ms Ingrid Cunningham, 175 Fifth Ave, New York, Ny 10010 Usa2008

Graph Chatbot

Chat with Graph Search

Ask any question about EPFL courses, lectures, exercises, research, news, etc. or try the example questions below.

DISCLAIMER: The Graph Chatbot is not programmed to provide explicit or categorical answers to your questions. Rather, it transforms your questions into API requests that are distributed across the various IT services officially administered by EPFL. Its purpose is solely to collect and recommend relevant references to content that you can explore to help you answer your questions.