Concept

Haematopoiesis

Related publications (140)

Biomechanical Induction of Hematopoiesis

The present invention provides methods and compositions for increasing the hematopoietic potential of a population of hematopoietic progenitor cells, vascular cells, and or hemogenic endothelium, by exposing the cells to at least one external biomechanical ...

2010

Notch signaling in the immune system

Freddy Radtke, Nicolas Fasnacht

The Notch signaling pathway regulates many aspects of embryonic development, as well as differentiation processes and tissue homeostasis in multiple adult organ systems. Disregulation of Notch signaling is associated with several human disorders, including ...

2010

Atopic dermatitis-like disease and associated lethal myeloproliferative disorder arise from loss of notch signaling in the murine skin

Freddy Radtke, Ute Koch, Matteo Di Piazza

BACKGROUND: The Notch pathway is essential for proper epidermal differentiation during embryonic skin development. Moreover, skin specific loss of Notch signaling in the embryo results in skin barrier defects accompanied by a B-lymphoproliferative disease. ...

Public Library of Science2010

In vitro and in vivo photocytotoxicity of boron dipyrromethene derivatives for photodynamic therapy

Hubert van den Bergh, Georges Wagnières, Patrycja Nowak-Sliwinska, Siang Hui Lim

To understand the effects of substitution patterns on photosensitizing the ability of boron dipyrromethene (BODIPY), two structural variations that either investigate the effectiveness of various iodinated derivatives to maximize the "heavy atom effect" or ...

American Chemical Society2010

Identification of genetic insulator elements to increase the safety of viral gene therapy vectors

Armelle Gaussin

Haematopoeitic system diseases, both acquired and inherited, can be currently cured by allogeneic haematopoietic stem cell transplantation. This treatment provides highly successful immune function recovery for patients receiving grafts of HLA-compatible d ...

EPFL2010

Methods for enhancing hematopoietic progenitor cell engraftment

Olaia Maria Naveiras Torres-Quiroga

Described herein are methods for improving engraftment of hematopoietic cells in an individual following hematopoietic progenitor cell transplantation (e.g., via bone marrow or cord blood transplantation). Methods for increasing hematopoietic progenitor ce ...

2010

Alternative promoter usage at the notch1 locus supports ligand-independent signaling in T cell development and leukemogenesis

Freddy Radtke, Jialin Zhang

Loss of the transcription factor Ikaros is correlated with Notch receptor activation in T cell acute lymphoblastic leukemia (T-ALL). However, the mechanism remains unknown. We identified promoters in Notch1 that drove the expression of Notch1 proteins in t ...

Elsevier2010

Hes1 Is a Critical but Context-Dependent Mediator of Canonical Notch Signaling in Lymphocyte Development and Transformation

Freddy Radtke, Ute Koch, Christelle Dubey, Agnieszka Anna Wendorff, Silvia Wirth

Although canonical Notch signaling regulates multiple hematopoietic lineage decisions including T cell and marginal zone B cell fate specification, the downstream molecular mediators of Notch function are largely unknown. We showed here that conditional in ...

Elsevier2010

Modeling and analysis of cell differentiation using hybrid systems

Maryam Kamgarpour

The capacity of cells to differentiate into specialized types is fundamental to the development of organisms. However, the underlying cell differentiation process is not yet well understood. In this work, we consider cell differentiation resulting from int ...

IEEE2010

Oncogenic activation of the Notch1 gene by deletion of its promoter in Ikaros-deficient T-ALL

Freddy Radtke

The Notch pathway is frequently activated in T-cell acute lymphoblastic leukemias (T-ALLs). Of the Notch receptors, Notch1 is a recurrent target of gain-of-function mutations and Notch3 is expressed in all T-ALLs, but it is currently unclear how these rece ...

2010

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