Publications associées à Cellular senescence

Platinum nanopetal-based potassium sensors for acute cell death monitoring

Giovanni De Micheli, Sandro Carrara, Irene Taurino

Growing interest in the role of ions as cell death regulators has led to the consideration of K+, which plays a major role in events such as necrosis, apoptosis and osmotic shock. These mechanisms induce effluxes of K+, which can be m ...

RSC Publishing2016

No DDRama at chromosome ends: TRF2 takes centre stage

Antonio Porro, Liuh-Yow Chen, Sascha Feuerhahn

Telomeres are nucleoprotein structures capping the natural termini of eukaryotic linear chromosomes. Telomeres possess an inherent ability to circumvent the activation of a full-blown DNA damage response (DDR), and hence fusion reactions, by limiting inapp ...

Elsevier Science London2015

Combined CSL and p53 downregulation promotes cancer-associated fibroblast activation

Cathrin Brisken, Melody Swartz, Witold Waldemar Kilarski, Csaba Ferenc László, Elena Menietti, Dania Al Labban

Stromal fibroblast senescence has been linked to ageing-associated cancer risk. However, density and proliferation of cancer-associated fibroblasts (CAFs) are frequently increased. Loss or downmodulation of the Notch effector CSL (also known as RBP-Jκ) in ...

Nature Publishing Group2015

Telomere functions grounding on TERRA firma

Joachim Lingner

Long noncoding telomeric repeat-containing RNAs TERRAs - are transcribed in a regulated manner from telomeres throughout eukaryotes. TERRA molecules consist of chromosome end-specific subtelomeric sequences and telomeric repeats at their 3' ends. Recent wo ...

Elsevier Science London2015

Alpha-Synuclein as a Mediator in the Interplay between Aging and Parkinson's Disease

Patrick Aebischer, Bernard Schneider, Wojciech Janusz Bobela

Accumulation and misfolding of the alpha-synuclein protein are core mechanisms in the pathogenesis of Parkinson's disease. While the normal function of alpha-synuclein is mainly related to the control of vesicular neurotransmission, its pathogenic effects ...

Mdpi Ag2015

Molecularly Engineered Self-Assembling Membranes for Cell-Mediated Degradation

Jeffrey Alan Hubbell, Daniela Sofia Dias Ferreira, Yi-An Lin

The use of peptide engineering to develop self-assembling membranes that are responsive to cellular enzyme activities is reported. The membranes are obtained by combining hyaluronan (HA) and a rationally designed peptide amphiphile (PA) containing a proteo ...

Wiley-Blackwell2015

Engineering antigen-specific immunological tolerance

Stephane Kontos, Jeffrey Alan Hubbell, Alizée Jéléna Grimm

Unwanted immunity develops in response to many protein drugs, in autoimmunity, in allergy, and in transplantation. Approaches to induce immunological tolerance aim to either prevent these responses or reverse them after they have already taken place. We pr ...

Current Biology Ltd2015

Characterization of intracellular metabolic states in the origin of the metabolic reprogramming of cancer cells

Vassily Hatzimanikatis, Meriç Ataman, Joana Raquel Pinto Vieira

Cancer cells have been observed to undergo a metabolic reprogramming in which glycolytic fluxes are upregulated whereas oxidative phosphorylation is downregulated. This metabolic phenotype is known as the Warburg effect and it is observed even under high o ...

2015

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Cellular senescence

KAT2A/KAT2B-targeted acetylome reveals a role for PLK4 acetylation in preventing centrosome amplification

Platinum nanopetal-based potassium sensors for acute cell death monitoring

No DDRama at chromosome ends: TRF2 takes centre stage

Combined CSL and p53 downregulation promotes cancer-associated fibroblast activation

Telomere functions grounding on TERRA firma

Alpha-Synuclein as a Mediator in the Interplay between Aging and Parkinson's Disease

Molecularly Engineered Self-Assembling Membranes for Cell-Mediated Degradation

The effect of warmer or cooler winters on European beech phenology carries over the phenophases of next growing season

Engineering antigen-specific immunological tolerance

Characterization of intracellular metabolic states in the origin of the metabolic reprogramming of cancer cells

Graph Chatbot

Chattez avec Graph Search

Platinum nanopetal-based potassium sensors for acute cell death monitoring

KAT2A/KAT2B-targeted acetylome reveals a role for PLK4 acetylation in preventing centrosome amplification

No DDRama at chromosome ends: TRF2 takes centre stage

Telomere functions grounding on TERRA firma

Combined CSL and p53 downregulation promotes cancer-associated fibroblast activation

Alpha-Synuclein as a Mediator in the Interplay between Aging and Parkinson's Disease

Characterization of intracellular metabolic states in the origin of the metabolic reprogramming of cancer cells

Molecularly Engineered Self-Assembling Membranes for Cell-Mediated Degradation

The effect of warmer or cooler winters on European beech phenology carries over the phenophases of next growing season

Engineering antigen-specific immunological tolerance