Concept

Gene knock-in

Related publications (93)

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Organohalide respiration (OHR) is a bacterial anaerobic respiratory metabolism dedicated to use halogenated compounds as terminal electron acceptors. OHR bacteria are strictly anaerobic microorganisms which use reductive dehalogenases (RdhA) as key enzymes ...

2012

A function for all posterior Hoxd genes during digit development?

Denis Duboule, Saskia Joëlle Delpretti Anex, Jozsef Zakany

Background: Four posterior Hoxd genes, from Hoxd13 to Hoxd10, are collectively regulated during the development of tetrapod digits. Besides the well-documented role of Hoxd13, the function of the neighboring genes has been difficult to evaluate due to the ...

2012

The importance of Hox genes in the specification of neuronal fates in the spinal cord has long been recognized. However, the transcriptional controls underlying their collinear expression domains remain largely unknown. Here we show in mice that the corres ...

2012

Purpose: Quantitative methylation-specific tests suggest that not all cells in a glioblastoma with detectable promoter methylation of the O6-methylguanine DNA methyltransferase (MGMT) gene carry a methylated MGMT allele. This observation may indicate cell ...

2011

Recently, two large independent genome-wide association studies have provided compelling evidence that polymorphisms at the phosphatidylinositol-binding clathrin assembly protein (PICALM) locus are linked to Alzheimer’s disease (AD). At the cellular level, ...

2011

Origins and consequences of transcriptional discontinuity

Felix Naef, David Michael Suter

In both prokaryotes and eukaryotes, transcription has been described as being temporally discontinuous, most genes being active mainly during short activity windows interspersed by silent periods. In mammalian cells, recent studies performed at the single ...

2011

GETPrime: a gene- or transcript-specific primer database for quantitative real-time PCR

Bart Deplancke, Jacques Rougemont, Fabrice David, Andreas Massouras, Alexandre Gattiker, Frederik Decouttere

The vast majority of genes in humans and other organisms undergo alternative splicing, yet the biological function of splice variants is still very poorly understood in large part because of the lack of simple tools that can map the expression profiles and ...

2011

A MART-1::Cre transgenic line induces recombination in melanocytes and RPE

Friedrich Beermann, Iraz Toprak Aydin

The number of transgenic mouse lines expressing Cre in either type of pigment cells (melanocytes and retinal pigment epithelium, RPE) is limited, and the available lines do not always offer sufficient specificity. In this study, we addressed this issue and ...

2011

Analysis of the Pigment Cell Specific Gene MART-1/Melan-A/mlana

Iraz Toprak Aydin

Pigmentation is a complex process that provides many diverse benefits for the organism. Pigment production takes place in the pigment cell lineage in dedicated organelles called melanosomes. Several proteins are specifically recruited to melanosomes for th ...

EPFL2010

Use of consensus sequences for the design of high density resequencing microarrays: the influenza virus paradigm

Stewart Cole, Iain Old

BACKGROUND: A resequencing microarray called PathogenID v2.0 has been developed and used to explore various strategies of sequence selection for its design. The part dedicated to influenza viruses was based on consensus sequences specific for one gene gene ...

BioMed Central2010

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