Concept

Lactic acid

Related publications (88)

Repair of critical size defects in the rat cranium using ceramic-reinforced PLA scaffolds obtained by supercritical gas foaming

Dominique Pioletti, Pierre-Etienne Bourban, Lee Ann Laurent-Applegate

Bioresorbable scaffolds made Of poly(L-lactic acid) (PLA) obtained by supercritical gas foaming were recently described as suitable for tissue engineering, portraying biocompatibility with primary osteoblasts in vitro and interesting mechanical properties ...

2007

Metabolic compartmentalization in the human cortex and hippocampus: evidence for a cell- and region-specific localization of lactate dehydrogenase 5 and pyruvate dehydrogenase

Pierre Magistretti, Luc Pellerin

BACKGROUND: For a long time now, glucose has been thought to be the main, if not the sole substrate for brain energy metabolism. Recent data nevertheless suggest that other molecules, such as monocarboxylates (lactate and pyruvate mainly) could be suitable ...

2007

Dynamics of lactate concentration and blood oxygen level-dependent effect in the human visual cortex during repeated identical stimuli

Rolf Gruetter

In vivo 1H NMR spectroscopy at 7 T was utilized to measure the changes in lactate concentration upon repeated identical visual stimuli, each lasting for 2 min. The average amplitude of these increases was found to be reduced over time (P < 0.01), from 0.13 ...

Wiley-Blackwell2007

Polylactic Acid–Phosphate Glass Composite Foams as Scaffolds for Bone Tissue Engineering

Dominique Pioletti, Pierre-Etienne Bourban

Phosphate glass (PG) of the composition 0.46(CaO)–0.04(Na2O)–0.5(P2O5) was used as filler in poly-L-lactic acid (PLA) foams developed as degradable scaffolds for bone tissue engineering. The effect of PG on PLA was assessed both in bulk and porous composit ...

2006

Effect of nanoparticle size on the extravasation and the photothrombic activity of meso(p-tetracarboxyphenyl)porphyrin

Hubert van den Bergh, Elodie Debefve

Particle size should be optimized to achieve targeted and extended drug delivery to the affected tissues. We describe here the effects of the mean particle size on the pharmacokinetics and photothrombic activity of meso-tetra(carboxyphenyl)porphyrin (TCPP) ...

Elsevier2006

Brain lactate kinetics: Modeling evidence for neuronal lactate uptake upon activation

Pierre Magistretti, Luc Pellerin

A critical issue in brain energy metabolism is whether lactate produced within the brain by astrocytes is taken up and metabolized by neurons upon activation. Although there is ample evidence that neurons can efficiently use lactate as an energy substrate, ...

2005

Biocompatibility of bioresorbable poly(L-lactic acid) composite scaffolds obtained by supercritical gas foaming with human fetal bone cells

Dominique Pioletti, Pierre-Etienne Bourban, Boris Hinz

The aim of this investigation was to test the biocompatibility of three-dimensional bioresorbable foams made of poly(L-lactic acid) (PLA), alone or filled with hydroxyapatite (HA) or beta-tricalcium phosphate (beta-TCP), with human primary osteoblasts, usi ...

2005

Processing of porous polymer composites for bone tissue engineering

Bone is a natural cellular composite, with a gradient structure going from a loose interconnected core to an outer dense wall, thus minimising bone weight while maintaining a high mechanical performance. Bone can be repaired using either auto- or allo- gra ...

EPFL2004

In situ product removal (ISPR) in whole cell biotechnology during the last twenty years

Urs von Stockar

This review sums up the activity in the field of in situ product removal in whole cell bioprocesses over the last 20 yr. It gives a complete summary of ISPR operations with microbial cells and cites a series of interesting ISPR applications in plant and an ...

Springer2003

Influence of residual ethanol concentration on the growth of Gluconacetobacter xylinus I 2281

Urs von Stockar, Ian William Marison, Henri Kornmann

The influence of residual ethanol on metab. of food grade Gluconacetobacter xylinum I 2281 was investigated during controlled cultivations on 35 g/l glucose and 5 g/l ethanol. Bacterial growth was strongly reduced in the presence of ethanol, which is unusu ...

Springer-Verlag2003

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