Concept

Ex vivo

Related publications (103)

Superparamagnetic iron oxide nanoparticles (SPIONs): from synthesis to in vivo studies - A summary of the synthesis, characterization, in vitro and in vivo investigations of SPIONs with particular focus on surface and colloidal properties

In this work, we present a short summary of the synthesis and characterization of superparamagnetic iron oxide nanoparticles and their behavior in vitro and in vivo. Therefore, we have used various characterization techniques to deduce the physical particl ...

2007

A composite biofoam, from research to in vivo validation

Dominique Pioletti, Pierre-Etienne Bourban

Bone tissue engineering aims at developing scaffolds, or porous structures, as supports for cell migration, proliferation and differentiation, in order to favor bone healing. L-poly lactic acid (PLA) foams, which were reinforced or not with β-tricalcium ph ...

2007

Structure-activity relationships for ruthenium(II)-arene drugs

Claudine Scolaro

The discovery of the anticancer properties of cisplatin in 1965 heralded the development of metallopharmaceuticals and founded a revolution in cancer therapy. Platinum drugs are believed to induce cytotoxicity by cross-linking DNA, causing changes to the D ...

EPFL2007

Effect of ACL rupture on knee biomechanics: in vivo measurements and finite element analyses

Cyntia Duc

Ce projet met en commun les connaissances de deux laboratoires de l'Institut de Biomécanique Translationnelle (IBME) : la mesure de la cinétique et de la cinématique du genou (LMAM), ainsi que l'analyse biomécanique de l'articulation en éléments finis (LBO ...

2007

Synthesis, Characterization, and in Vitro Evaluation of Novel Ruthenium(II) η6-Arene Imidazole Complexes

Paul Joseph Dyson, Andrew Douglas Phillips, Claudine Scolaro, Gianni Sava

Ten complexes of general formula [Ru(η6-arene)Cl2(L)], [Ru(η6-arene)Cl(L)2][X], and [Ru(η6-arene)(L)3][X]2 (η6-arene = benzene, p-cymene; L = imidazole, ...

2006

Autofluorescence detection of tumors in the human lung -comparison between in-vivo and in vitro measurements

Georges Wagnières, Tanja Gabrecht

To detect bronchial carcinoma by autofluorescence, we measured in-vivo, in an in-vivo model, and in-vitro the spectra of tumor and normal tissue by a fiber-optic-spectrometer. The main difference between tumor and bronchial tissue is the intensity of the 5 ...

2005

In vitro and in vivo evaluation of ruthenium(II)-arene PTA complexes

Paul Joseph Dyson, Gabor Laurenczy, Claudine Scolaro, Gianni Sava

The antitumor activity of the organometallic ruthenium(II)-arene complexes, RuCl2(eta(6)-arene)(PTA), (arene = p-cymene, toluene, benzene, benzo-15-crown-5, 1-ethylbenzene-2,3-dimethylimidazolium tetrafluoroborate, ethyl benzoate, hexamethylbenzene; PTA = ...

2005

In vivo measurement of glucose utilization in rats using a beta-microprobe: direct comparison with autoradiography

Pierre Magistretti, Jean-Marie Petit, Christian Morel

A new beta-microprobe (betaP) has been used to locally measure the time-concentration curve of a radiolabeled substance. The betaP, analogous to positron emission tomography methodology, is useful for in vivo animal studies because it can acquire time-conc ...

2004

Lentiviral-mediated gene transfer to model triplet repeat disorders

Patrick Aebischer, Diana Zala

This chapter describes the potential use of viral-mediated gene transfer in the central nervous system as a new strategy in developing animal models of neurodegenerative diseases. To illustrate the approach, procedures for the production of lentiviral vect ...

2004

Polyelectrolyte-based immunprotection systems

The research of this doctoral thesis was dedicated to polyelectrolytes, specifically to hydrogel materials, which result from coacervation and polyelectrolyte complex formation and have a potential as immunoprotection systems. In particular, microspheres o ...

EPFL2004

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