Publications related to Thrombosis

Time-domain algorithm for single-photon laser-Doppler flowmetry at large interoptode spacing in human bone

A new laser-Doppler flowmeter at large interoptode spacing, based on single-photon counting (single-photon laser-Doppler flowmetry [SP-LDF]) and allowing assessment of blood flow deep in bone tissue, is proposed and implemented. To exploit the advantages o ...

Optical Soc Amer2014

Development of a selective peptide macrocycle inhibitor of coagulation factor XII toward the generation of a safe antithrombotic therapy

Christian Heinis, Philippe Diderich, Vanessa Baeriswyl

Inhibition of coagulation factor XII (FXII) activity represents an attractive approach for the treatment and prevention of thrombotic diseases. The few existing FXII inhibitors suffer from low selectivity. Using phage display combined to rational design, w ...

2013

PHD2 regulates arteriogenic macrophages through TIE2 signalling

Michele De Palma, Mario Leonardo Squadrito, Ferdinando Pucci

Occlusion of the main arterial route redirects blood flow to the collateral circulation. We previously reported that macrophages genetically modified to express low levels of prolyl hydroxylase domain protein 2 (PHD2) display an arteriogenic phenotype, whi ...

Wiley-Blackwell2013

Proteolytic Processing Regulates Placental Growth Factor Activities

Jeffrey Alan Hubbell, Stéphanie Elisabeth Metzger, Martin Ehrbar, Manuel Koch

Placental growth factor (PlGF) is a critical mediator of blood vessel formation, yet mechanisms of its action and regulation are incompletely understood. Here we demonstrate that proteolytic processing regulates the biological activity of PlGF. Specificall ...

Amer Soc Biochemistry Molecular Biology Inc2013

The promotion of endothelial cell attachment and spreading using FNIII10 fused to VEGF-A(165)

Jeffrey Alan Hubbell, Melody Swartz, Mikaël Martino

Synergy in the downstream signaling pathways of the vascular endothelial growth factor receptor-2 (VEGFR-2) and the integrin alpha v beta 3 is critical for blood vessel formation. Thus, agents that activate both receptors could possess efficient pro-angiog ...

Elsevier2013

A Fast pH-Switchable and Self-Healing Supramolecular Hydrogel Carrier for Guided, Local Catheter Injection in the Infarcted Myocardium

Maartje Martina Cornelia Bastings

Minimally invasive intervention strategies after myocardial infarction use state-of-the-art catheter systems that are able to combine mapping of the infarcted area with precise, local injection of drugs. To this end, catheter delivery of drugs that are not ...

Wiley-VCH Verlag2013

The Angiotensin-Converting Enzyme 2/Angiotensin-(1-7)/Mas receptor axis: A potential target for treating thrombotic diseases

Nikolaos Stergiopoulos, Danielle Gomes Passos Silva

Despite many therapeutic advances leading to increasingly effective drug treatments, thrombotic events (such as ischaemic stroke, pulmonary embolism, deep venous thrombosis and acute myocardial infarction) still represent a major worldwide cause of morbidi ...

Schattauer Gmbh-Verlag Medizin Naturwissenschaften2012

Wall properties of the apolipoprotein E-deficient mouse aorta

Nikolaos Stergiopoulos, Aristotelis Agianniotis

Objectives: We quantified the dysfunction of the aortic wall, determined structural and elastic properties, and provided histological data of the thoracic aortas of apolipoprotein E (apoE)-deficient mice which are used as model of atherosclerosis. Methods: ...

Elsevier Ireland Ltd2012

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Thrombosis

Time-domain algorithm for single-photon laser-Doppler flowmetry at large interoptode spacing in human bone

Living-Engineered Valves for Transcatheter Venous Valve Repair

Development of a selective peptide macrocycle inhibitor of coagulation factor XII toward the generation of a safe antithrombotic therapy

PHD2 regulates arteriogenic macrophages through TIE2 signalling

Proteolytic Processing Regulates Placental Growth Factor Activities

The promotion of endothelial cell attachment and spreading using FNIII10 fused to VEGF-A(165)

A Fast pH-Switchable and Self-Healing Supramolecular Hydrogel Carrier for Guided, Local Catheter Injection in the Infarcted Myocardium

The Angiotensin-Converting Enzyme 2/Angiotensin-(1-7)/Mas receptor axis: A potential target for treating thrombotic diseases

Portable Technologies for Self-Monitoring of Coagulation Time: A Review

Wall properties of the apolipoprotein E-deficient mouse aorta

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Chat with Graph Search

Proteolytic Processing Regulates Placental Growth Factor Activities

Living-Engineered Valves for Transcatheter Venous Valve Repair

The promotion of endothelial cell attachment and spreading using FNIII10 fused to VEGF-A(165)

Time-domain algorithm for single-photon laser-Doppler flowmetry at large interoptode spacing in human bone

Development of a selective peptide macrocycle inhibitor of coagulation factor XII toward the generation of a safe antithrombotic therapy

A Fast pH-Switchable and Self-Healing Supramolecular Hydrogel Carrier for Guided, Local Catheter Injection in the Infarcted Myocardium

PHD2 regulates arteriogenic macrophages through TIE2 signalling

The Angiotensin-Converting Enzyme 2/Angiotensin-(1-7)/Mas receptor axis: A potential target for treating thrombotic diseases

Portable Technologies for Self-Monitoring of Coagulation Time: A Review

Wall properties of the apolipoprotein E-deficient mouse aorta