Concept

Rodent

Related publications (59)

Understanding the role of antibodies in murine infections with Heligmosomoides (polygyrus) bakeri: 35 years ago, now and 35 years ahead

The rodent intestinal nematode H.p.bakeri has played an important role in the exploration of the host–parasite relationship of chronic nematode infections for over six decades, since the parasite was first isolated in the 1950s by Ehrenford. It soon became ...

Wiley-Blackwell2014

Growth Factors Engineered for Super-Affinity to the Extracellular Matrix Enhance Tissue Healing

Jeffrey Alan Hubbell, Melody Swartz, Mikaël Martino, Witold Waldemar Kilarski, Priscilla Suhasna Maithili Briquez, Esra Güç, Federico Tortelli, Stéphanie Elisabeth Metzger, Jeffrey James Rice

Growth factors (GFs) are critical in tissue repair, but their translation to clinical use has been modest. Physiologically, GF interactions with extracellular matrix (ECM) components facilitate localized and spatially regulated signaling; therefore, we rea ...

Amer Assoc Advancement Science2014

Neuroprosthetic rehabilitation and translational mechanism after severe spinal cord injury

Lucia Florinda Friedli Wittler

Traumatic SCIs have long-term health, economic and social consequences, stressing the urgency to develop interventions to improve recovery after such injuries. Today, the only proven effective interventions to enhance recovery after SCI are activity-based ...

EPFL2014

Corticospinal neuroprostheses to restore locomotion after spinal cord injury

José del Rocio Millán Ruiz, Silvestro Micera, Stéphanie Lacour, Grégoire Courtine, Eduardo Martin Moraud, Pavel Musienko, Ivan Rusev Minev, Nikolaus Wenger, Marco Bonizzato, Janine Beauparlant, David Allenson Borton

In this conceptual review, we highlight our strategy for, and progress in the development of corticospinal neuroprostheses for restoring locomotor functions and promoting neural repair after thoracic spinal cord injury in experimental animal models. We spe ...

Elsevier2014

Effects of adverse early-life events on aggression and anti-social behaviours in animals and humans

Maria del Carmen Sandi Perez

We review here the impact of early adversities on the development of violence and antisocial behaviour in humans, and present three etiological animal models of escalated rodent aggression, each disentangling the consequences of one particular adverse earl ...

Wiley-Blackwell2014

Continental-Scale Footprint of Balancing and Positive Selection in a Small Rodent (Microtus arvalis)

Matthieu Foll

Genetic adaptation to different environmental conditions is expected to lead to large differences between populations at selected loci, thus providing a signature of positive selection. Whereas balancing selection can maintain polymorphisms over long evolu ...

Public Library of Science2014

Development and implementation of ¹H magnetic resonance techniques for an improved in vivo assessment of models of cerebral metabolic disorders

Mélanie Craveiro

Nuclear magnetic resonance (NMR) is a physical phenomenon that is widely used in the biomedical field due to its non-invasive and non-destructive properties, which make it an optimal tool for the in vivo investigation of living organs such as the brain. Th ...

EPFL2013

Autonomous and self-sustained circadian oscillators displayed in human islet cells

Michaël Unser, Daniel Sage, Christophe Bauer

Following on from the emerging importance of the pancreas circadian clock on islet function and the development of type 2 diabetes in rodent models, we aimed to examine circadian gene expression in human islets. The oscillator properties were assessed in i ...

Springer2013

Increased performance in genetic manipulation by modeling the dielectric properties of the rodent brain

Diego Ghezzi

Genetic approaches to control DNA expression in different brain areas have provided an excellent system to characterize gene function in health and disease of animal models. With respect to others, in utero electroporation of exogenous DNA into progenitor ...

2013

Animal Models of Neurologic Disorders: A Nonhuman Primate Model of Spinal Cord Injury

Grégoire Courtine

Primates are an important and unique animal resource. We have developed a nonhuman primate model of spinal cord injury (SCI) to expand our knowledge of normal primate motor function, to assess the impact of disease and injury on sensory and motor function, ...

2012

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