Concept

Precancerous condition

Related publications (38)

Invasive and indigenous microbiota impact intestinal stem cell activity through multiple pathways in Drosophila

Bruno Lemaitre, Nichole Broderick, Sveta Chakrabarti

Gut homeostasis is controlled by both immune and developmental mechanisms, and its disruption can lead to inflammatory disorders or cancerous lesions of the intestine. While the impact of bacteria on the mucosal immune system is beginning to be precisely u ...

2009

Thrombin-sensitive photodynamic agents: A novel strategy for selective synovectomy in rheumatoid arthritis

Hubert van den Bergh

Protease-sensitive macromolecular prodrugs have attracted interest for bio-responsive drug delivery to sites with up-regulated proteolytic activities such as inflammatory or cancerous lesions. Here we report the development of a novel polymeric photosensit ...

2009

Blue-violet excited autofluorescence spectroscopy and imaging of normal and cancerous human bronchial tissue after formalin fixation

Georges Wagnières, Tanja Gabrecht

Autofluorescence (AF) imaging is a powerful tool for the detection of (pre-)neoplastic lesions in the bronchi. Several endoscopic imaging systems exploit the spectral and intensity contrast of AF between healthy and (pre-)neoplastic bronchial tissues, yet, ...

Wiley-Blackwell2007

An oestrogen-dependent model of breast cancer created by transformation of normal human mammary epithelial cells

Cathrin Brisken, Stéphanie Joëlle André, Maryse Fiche

INTRODUCTION: About 70% of breast cancers express oestrogen receptor alpha (ESR1/ERalpha) and are oestrogen-dependent for growth. In contrast with the highly proliferative nature of ERalpha-positive tumour cells, ERalpha-positive cells in normal breast tis ...

2007

Kernel Methods for Melanoma Recognition

Barbara Caputo, Tatiana Tommasi

Skin cancer is a spreading disease in the western world. Early detection and treatment are crucial for improving the patient survival rate. In this paper we present two algorithms for computer assisted diagnosis of melanomas. The first is the support vecto ...

2006

Kernel Methods for Melanoma Recognition

Barbara Caputo, Tatiana Tommasi

Malignant melanoma is the most deadly for of skin lesion. Early diagnosis is of critical importance to patient survival. Visual recognition algorithms could potentially be of great help for physicians in a computer assisted diagnosis system. Previous work ...

2006

Notch1 can contribute to viral-induced transformation of primary human keratinocytes

Peter Martin Beard

The human papillomavirus (HPV) is the most significant causative agent in the development of cervical cancer. Despite its presence in almost all cervical cancers, HPV by itself is unable to transform a normal cell to a cancerous one. Instead, additional ce ...

2003

In vivo fluorescence spectroscopy to optimize the detection of early bronchial carcinoma by autofluorescence imaging

Hubert van den Bergh, Georges Wagnières, Matthieu Philippe Emmanuel Zellweger

Autofluorescence bronchoscopy is a promising approach to detect and characterize precancerous and early cancerous lesions. Nevertheless, many spectral features of photodetection systems remain unclear and sub-optimal at the present time. We report here a c ...

2002

Evolution of DNA ploidy during squamous cell carcinogenesis in the esophagus

Image and flow cytometry was used to study the nuclear DNA content (ploidy) during the squamous cell carcinogenesis in the esophagus. The present retrospective study comprised 26 surgical specimens of squamous cell carcinomas (SCC) in patients who underwen ...

2002

Time-resolved autofluorescence spectroscopy of the bronchial mucosa for the detection of early cancer: Clinical results

Hubert van den Bergh, Georges Wagnières, Tanja Gabrecht, Pascal Uehlinger

Time-resolved measurements of endogenous tissue autofluorescence were carried out on the bronchial mucosa of 18 patients during endoscopy by the means of an optical fibre-based spectrometer. The objective was to assess the fluorescence lifetime as a new co ...

2001

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