Concept

ClinicalTrials.gov

Related publications (15)

Increased invasiveness of MMP-9-deficient tumors in two mouse models of neuroendocrine tumorigenesis

Despite their apparent success in pre-clinical trials, metalloproteinase (MMP) inhibitors proved to be inefficacious in clinical settings. In an effort to understand the underlying causes of this unanticipated outcome, we modeled the consequences of long-t ...

2013

A Handheld Intra-Operative beta(+) Sensing System

Edoardo Charbon, Claudio Bruschini, Marco Matter, Christian Mester

We present a new, handheld system for in vivo detection of radiotracers. The detection is based on scintillators coupled to Silicon Photomultipliers (SiPMs) and aimed at direct positron detection. The battery-powered system is wire-lessly connected to a PC ...

Elsevier Science, Reg Sales Off, Customer Support Dept, 655 Ave Of The Americas, New York, Ny 10010 Usa2011

Bioanalytical and biophysical techniques for the elucidation of the mode of action of metal-based drugs

Paul Joseph Dyson, Michael Groessl

Platinum-based drugs present one of the pillars of anticancer chemotherapy, and pharmaceuticals incorporating metals such as ruthenium, gallium, titanium and gold, some of which have already entered clinical trials, show promising features including activi ...

2011

High-titer, serum-free production of adeno-associated virus vectors by polyethyleneimine-mediated plasmid transfection in mammalian suspension cells

Florian Maria Wurm, Lucia Baldi Unser, Mathieu Benjamin Stettler

Adeno-associated virus (AAV)-based vectors belong to the most promising gene transfer vectors in clinical studies. To provide vector for late-stage clinical trials as well as for a potential commercial phase, a scalable, cGMP-compliant process is required. ...

2007

High-titer, serum-free production of adeno-associated virus vectors by polyethyleneimine-mediated plasmid transfection in mammalian suspension cells

Florian Maria Wurm, Lucia Baldi Unser, Mathieu Benjamin Stettler

Springer, Springer Netherlands2007

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