Concept

Sense of smell

Related publications (84)

Dual activities of odorants on olfactory and nuclear hormone receptors

Horst Vogel, Horst Pick, Olivia Baud, Sylvain Etter, Ralf Schmauder

We have screened an odorant compound library and discovered molecules acting as chemical signals that specifically activate both G-protein-coupled olfactory receptors (ORs) on the cell surface of olfactory sensory neurons and the human nuclear estrogen rec ...

American Society for Biochemistry and Molecular Biology2009

Large-scale production and study of a synthetic G protein-coupled receptor: Human olfactory receptor 17-4

Horst Vogel, Horst Pick

Although understanding of the olfactory system has progressed at the level of downstream receptor signaling and the wiring of olfactory neurons, the system remains poorly understood at the molecular level of the receptors and their interaction with and rec ...

National Academy of Sciences2009

Imaging of G protein-coupled receptors in solid-supported planar lipid membranes

Theo Lasser, Marcel Leutenegger

This contribution summarizes first some of our efforts in imaging G-protein-coupled receptor (GPCR) functional inserted into planar tethered lipid bilayer membranes (tBLMs) as a novel platform for biophysical studies. The authors introduced recently a nove ...

2009

Indo-1 derivatives for local calcium sensing

Kai Johnsson, Annina Aebischer, Cindy Fellay

The role of calcium in signal transduction relies on the precise spatial and temporal control of its concentration. The existing means to detect fluctuations in Ca2+ concentrations with adequate temporal and spatial resolution are limited. We introduce her ...

American Chemical Society2009

Alteration of brain glycogen turnover in the conscious rat after 5h of prolonged wakefulness

Rolf Gruetter, Pierre Magistretti, Bernard Lanz, Jean-Marie Petit, Hanne Frenkel

Although glycogen (Glyc) is the main carbohydrate storage component, the role of Glyc in the brain during prolonged wakefulness is not clear. The aim of this study was to determine brain Glyc concentration ([]) and turnover time (tau) in euglycemic conscio ...

2009

Localizing an Odor Source and Avoiding Obstacles: Experiments in a Wind Tunnel using Real Robots

Alcherio Martinoli, Thomas Lochmatter, Nicolas Heiniger

We report on real-robot odor source localization experiments carried out in an environment with obstacles in the odor plume. The robot was equipped with an ethanol sensor and a wind direction sensor, and the experiments were carried out in a wind tunnel, i ...

2009

Modified Trans-synaptic Tracing Viruses Reveal Novel Connectivity in the Rat Olfactory Bulb

Aurélie Pala

Olfaction and the olfactory pathway is a good system to study sensory processing in general, mainly because of the simplified organization of the cells constituting the olfactory bulb, the anatomical structure responsible for early odor encoding and proces ...

2008

Nanobiosensors based on individual olfactory receptors

Luis Guillermo Villanueva Torrijo

The animal olfactory system represents the gold standard of biosensors, due to its ability to identify and discriminate thousands of odorant compounds with very low thresholds. Using olfactory receptors (ORs) as sensing elements instead of chemical sensors ...

2008

A Comparison of Casting and Spiraling Algorithms for Odor Source Localization in Laminar Flow

Alcherio Martinoli, Thomas Lochmatter, Xavier Raemy, Saurabh Indra

We compare two well-known algorithms for locating odor sources in environments with a main wind flow. Their plume tracking performance is tested through systematic experiments with real robots in a wind tunnel under laminar flow condition. We present the s ...

2008

Gamma Oscillations in a Nonlinear Regime: A Minimal Model Approach Using Heterogeneous Integrate-and-Fire Networks

Brice Bathellier

Fast oscillations and in particular gamma-band oscillation (20-80 Hz) are commonly observed during brain function and are at the center of several neural processing theories. In many cases, mathematical analysis of fast oscillations in neural networks has ...

Massachusetts Institute of Technology Press2008

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