Concept

Spinal cord

Related publications (389)

Brain-controlled neuroprosthetic interventions to restore locomotion after contusion spinal cord injury in the rat

Spinal cord injury (SCI), second only to stroke, is the leading cause of paralysis. Therapies based on electrical stimulation of the spinal cord and other locomotor areas of the Nervous System improve motor control in people with neurotrauma. Neuromodulati ...

EPFL2017

Biodegradable scaffolds promote tissue remodeling and functional improvement in non-human primates with acute spinal cord injury

Grégoire Courtine, Isabel Laura Vollenweider

Tissue loss significantly reduces the potential for functional recovery after spinal cord injury. We previously showed that implantation of porous scaffolds composed of a biodegradable and biocompatible block copolymer of Poly-lactic-co-glycolic acid and P ...

2017

Sustained enhancements in inhibitory control depend primarily on the reinforcement of fronto-basal anatomical connectivity

Bogdan Draganski, Wietske Van der Zwaag, Michaël Mouthon

What are the neurophysiological determinants of sustained supra-normal inhibitory control performance? We addressed this question by coupling multimodal neuroimaging and behavioral investigations of experts in fencing who underwent more than 20,000 h of in ...

Springer Heidelberg2017

Interactions between the corticospinal tract and premotor-motor pathways in stroke recovery

Friedhelm Christoph Hummel

Background and Purpose-Brain imaging has continuously enhanced our understanding how different brain networks contribute to motor recovery after stroke. However, the present models are still incomplete and do not fit for every patient. The interaction betw ...

American Heart Association2017

The Human Central Pattern Generator for Locomotion: Does It Exist and Contribute to Walking?

Auke Ijspeert, Florin Dzeladini, Karen Minassian

The ability of dedicated spinal circuits, referred to as central pattern generators (CPGs), to produce the basic rhythm and neural activation patterns underlying locomotion can be demonstrated under specific experimental conditions in reduced animal prepar ...

Sage Publications Inc2017

Modelling Neuromuscular Function of SCI Patients in Balancing

Arash Arami, Etienne Burdet

A novel neuromechanical model for investigating patient-specific lower limb movement dynamics after spinal cord injury (SCI) is presented. The model is designed in joint space and takes into account muscle neuromechanics. Application of the model is demons ...

Springer2017

The importance of neuronal networks for motor rehabilitation after a stroke

Friedhelm Christoph Hummel

Every year in Europe 1.5 million patients suffer a new stroke. Despite the further developments in acute therapy with nationwide stroke units, thrombolysis, thrombectomy and post-acute neurorehabilitation, only a small proportion of patients recover to a s ...

Springer Verlag2017

A multidirectional gravity-assist algorithm that enhances locomotor control in patients with stroke or spinal cord injury

Auke Ijspeert, Grégoire Courtine, Jocelyne Bloch, Joachim von Zitzewitz, Nicolas Francis Fumeaux, Marco Capogrosso, Rubia van den Brand, Jean-Baptiste Mignardot, Selin Anil, Jessica Lanini

Gait recovery after neurological disorders requires remastering the interplay between body mechanics and gravitational forces. Despite the importance of gravity-dependent gait interactions and active participation for promoting this learning, these essenti ...

Amer Assoc Advancement Science2017

Rich cell-type-specific network topology in neocortical microcircuitry

Henry Markram, Eilif Benjamin Muller, Srikanth Ramaswamy, Michael Reimann, Idan Segev, Eyal Gal, Michael London

Uncovering structural regularities and architectural topologies of cortical circuitry is vital for understanding neural computations. Recently, an experimentally constrained algorithm generated a dense network reconstruction of a similar to 0.3-mm(3) volum ...

Nature Publishing Group2017

Selective electrical and optical neuromodulation of the central nervous system with conformable microfabricated implants

Amélie Anne Guex

Neuroprosthetic systems are designed to interface with the nervous system, for the replacement or restoration of damaged functions in the motor and/or sensory systems. In order to have an efficient communication with the nervous tissue leading to optimized ...

EPFL2017

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