Concept

Spinal cord

Related publications (389)

Branched Lateral Tail Fiber Organization in T5-Like Bacteriophages DT57C and DT571/2 is Revealed by Genetic and Functional Analysis

Ricardo Cesar Guerrero Ferreira, Nikolai Prokhorov

The T5-like siphoviruses DT57C and DT571/2, isolated from horse feces, are very closely related to each other, and most of their structural proteins are also nearly identical to T5 phage. Their LTFs (L-shaped tail fibers), however, are composed of two prot ...

Mdpi Ag2016

The Oxygen Sensor PHD2 Controls Dendritic Spines and Synapses via Modification of Filamin A

Michele Giugliano

Neuronal function is highly sensitive to changes in oxygen levels, but how hypoxia affects dendritic spine formation and synaptogenesis is unknown. Here we report that hypoxia, chemical inhibition of the oxygen-sensing prolyl hydroxylase domain proteins (P ...

Elsevier2016

Flexibility of the axial central pattern generator network for locomotion in the salamander

Auke Ijspeert, Alessandro Crespi, Jérémie Knüsel

In tetrapods, limb and axial movements are coordinated during locomotion. It is well established that inter- and intralimb coordination show considerable variations during ongoing locomotion. Much less is known about the flexibility of the axial musculoske ...

Amer Physiological Soc2015

Simultaneous submicrometric 3D imaging of the micro-vascular network and the neuronal system in a mouse spinal cord

Peter Modregger, Giuseppe Battaglia

Faults in vascular (VN) and neuronal networks of spinal cord are responsible for serious neurodegenerative pathologies. Because of inadequate investigation tools, the lacking knowledge of the complete fine structure of VN and neuronal system represents a c ...

Nature Publishing Group2015

Pronounced species divergence in corticospinal tract reorganization and functional recovery after lateralized spinal cord injury favors primates

Grégoire Courtine, Quentin Barraud, Pavel Musienko, Rubia van den Brand, Lucia Florinda Friedli Wittler

Experimental and clinical studies suggest that primate species exhibit greater recovery after lateralized compared to symmetrical spinal cord injuries. Although this observation has major implications for designing clinical trials and translational therapi ...

American Association for the Advancement of Science2015

Muscle synergies and spinal maps are sensitive to the asymmetry induced by a unilateral stroke

Silvestro Micera, Martina Coscia

Background: Previous studies have shown that a cerebrovascular accident disrupts the coordinated control of leg muscles during locomotion inducing asymmetric gait patterns. However, the ability of muscle synergies and spinal maps to reflect the redistribut ...

Biomed Central Ltd2015

Neuroprosthetic technologies to augment the impact of neurorehabilitation after spinal cord injury

Silvestro Micera, Grégoire Courtine, Jocelyne Bloch, Eduardo Martin Moraud, Joachim von Zitzewitz, Nicolas Francis Fumeaux, Marco Capogrosso, Rubia van den Brand, Fabien Bertrand Paul Wagner, Jean-Baptiste Mignardot

Spinal cord injury leads to a range of disabilities, including limitations in locomotor activity, that seriously diminish the patients’ autonomy and quality of life. Electrochemical neuromodulation therapies, robot-assisted rehabilitation and willpower-bas ...

2015

On evaluating the accuracy and biological plausibility of diffusion MRI tractograms

Jean-Philippe Thiran, David Paul Roger Romascano, Alessandro Daducci

One of the major limitations of diffusion MRI tractography is that the tractograms, i.e. set of fiber tracts, recovered by existing algorithms are not truly quantitative. Hence, the structural connectivity between different brain regions, a.k.a. connectomi ...

2015

Evaluation of automatic neonatal brain segmentation algorithms: The NeoBrainS12 challenge

Elda Fischi Gomez, Laura Ioana Gui

A number of algorithms for brain segmentation in preterm born infants have been published, but a reliable comparison of their performance is lacking. The NeoBrainS12 study (http://neobrains12.isi.uu.nl), providing three different image sets of preterm born ...

Elsevier Science Bv2015

Biomaterials. Electronic dura mater for long-term multimodal neural interfaces

Silvestro Micera, Stéphanie Lacour, Grégoire Courtine, Eduardo Martin Moraud, Quentin Barraud, Léonie Asboth, Tomislav Milekovic, Marco Capogrosso, Pavel Musienko, Nicolas Vachicouras, Ivan Rusev Minev, Nikolaus Wenger, Jérôme Gandar, Arthur Edouard Hirsch, Natalia Pavlova, Simone Ellen Joze Duis

The mechanical mismatch between soft neural tissues and stiff neural implants hinders the long-term performance of implantable neuroprostheses. Here, we designed and fabricated soft neural implants with the shape and elasticity of dura mater, the protectiv ...

American Association for the Advancement of Science2015

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