Concept

Prenatal development

Related publications (163)

Hyper-emotional neurophysiology in a rat model of autism

Autism is a pervasive neurodevelopmental disorder of unknown etiology, characterized by a spectrum of symptoms of social impairment, abnormal communication, and unusual restricted, inflexible behaviors. Patients also frequently present various levels of se ...

EPFL2013

Stem cells living with a Notch

Freddy Radtke, Ute Koch, Rajwinder Lehal

Notch signaling has been shown over the past few decades to play fundamental roles in a plethora of developmental processes in an evolutionarily conserved fashion. Notch-mediated cell-to-cell signaling is involved in many aspects of embryonic development a ...

Company of Biologists2013

Vertical transmission of a Drosophila endosymbiont via cooption of the yolk transport and internalization machinery

Bruno Lemaitre, Fanny Schüpfer, Juan Camilo Paredes Escobar, Jeremy Keith Herren

Spiroplasma is a diverse bacterial clade that includes many vertically transmitted insect endosymbionts, including Spiroplasma poulsonii, a natural endosymbiont of Drosophila melanogaster. These bacteria persist in the hemolymph of their adult host and exh ...

American Society for Microbiology2013

Embryonic stem cell-based screen for small molecules: cluster analysis reveals four response patterns in developing neural cells

David Michael Suter, Mathurin Baquié

Neural differentiation of embryonic stem cells (ESC) is considered a promising model to perform in vitro testing for neuroactive and neurotoxic compounds. We studied the potential of a dual reporter murine ESC line to identify bioactive and/or toxic compou ...

2013

Prenatally engineered autologous amniotic fluid stem cell-based heart valves in the fetal circulation

Peter Modregger, Marco Stampanoni, Markus Rudin, Chad Brokopp, Marc Farine

Prenatal heart valve interventions aiming at the early and systematic correction of congenital cardiac malformations represent a promising treatment option in maternal-fetal care. However, definite fetal valve replacements require growing implants adaptive ...

2012

Using an adaptive gene network model for self-organizing multicellular behavior

Ali H. Sayed

Using the transient interleukin (IL)-2 secretion of effector T helper (Teff) cells as an example, we show that self-organizing multicellular behavior can be modeled and predicted by an adaptive gene network model. Incorporating an adaptation algorithm we e ...

IEEE2012

High-field diffusion tensor imaging characterization of cerebral white matter injury in lipopolysaccharide-exposed fetal sheep

Yohan Van de Looij, François Lazeyras

BACKGROUND: In gyrencephalic species such as sheep, precise anatomical and microstructural characterization of the consequences of fetal inflammation remains scarce. The goal of this study was to characterize changes in white matter (WM) structure using ad ...

Lippincott, Williams & Wilkins2012

The KRAB-ZFP/KAP1 System Contributes to the Early Embryonic Establishment of Site-Specific DNA Methylation Patterns Maintained during Development

Didier Trono, Priscilla Turelli, Charlène Mireille Raymonde Raclot, Sandra Eloise Kjeldsen, Adamantia Kapopoulou, Karolina Bojkowska

De novo DNA methylation is an essential aspect of the epigenetic reprogramming that takes place during early development, yet factors responsible for its instatement at particular genomic loci are poorly defined. Here, we demonstrate that the KRAB-ZFP-medi ...

Elsevier2012

Angiostatic kinase inhibitors to sustain photodynamic angio-occlusion

Hubert van den Bergh, Patrycja Nowak-Sliwinska, Blaise Lovisa

Targeted angiostatic therapy receives major attention for the treatment of cancer and exudative age-related macular degeneration (AMD). Photodynamic therapy (PDT) has been used as an effective clinical approach for these diseases. Since PDT can cause an an ...

2012

Cutting the fat: Artificial muscle oscillators for lighter, cheaper, and slimmer devices

Herbert Shea, Samuel Rosset

Artificial muscles based on dielectric elastomers show enormous promise for a wide range of applications and are slowly moving from the lab to industry. One problem for industrial uptake is the expensive, rigid, heavy and bulky high voltage driver, sensor ...

SPIE2012

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