Concept

Ligand (biochemistry)

Related publications (451)

Synthesis and Characterization of a Series of Model Complexes of the Active Site of [Fe]-Hydrogenase (Hmd)

A series of Fe complexes were synthesized and characterized as small molecule mimics for the active site of [Fe]-hydrogenase (Hmd). The collection includes both structurally new compounds and analogues of previously reported models. These complexes contain ...

2011

MULTI-ANALYTE DETECTION FOR BIOLOGICAL FLUIDS Towards Continous Monitoring of Glucose, Ionized Calcium and pH using a Viscometric Affinity Biosensor

Peter Ryser, Eric Meurville, Christophe Boss, Frédéric Schmitt, Pablo Dosil Rosende

We present a viscometric affinity biosensor that can potentially allow continuous multi-analyte monitoring in biological fluids like blood or plasma. The sensing principle is based on the detection of viscosity changes of a polymeric solution which has a s ...

SciTePress2011

Binding of Biotin to Streptavidin: A combined fluorescence correlation spectroscopy and time-resolved fluorescence study

Mostafa Shalaby

The Biotin-Streptavidin complex is a widely studied system in biology and biophysics, because of its extremely strong non-covalent binding affinity. The latter is often exploited to link molecules to substrates or to one another. However, the details of th ...

2011

From Phage Display to Dendrimer Display: Insights into Multivalent Binding

Maartje Martina Cornelia Bastings

Phage display is widely used for the selection of target-specific peptide sequences. Presentation of phage peptides on a multivalent platform can be used to (partially) restore the binding affinity. Here, we present a detailed analysis of the effects of va ...

American Chemical Society2011

Periplasmic Binding Proteins as Optical Modulators of Single-Walled Carbon Nanotube Fluorescence: Amplifying a Nanoscale Actuator

Ardemis Anoush Boghossian

The authors use glucose-binding protein (GBP) to mech. actuate a fluorescent single-walled carbon nanotube (SWNT), resulting in reversible exciton quenching in response to glucose. The GBP is covalently conjugated with carboxylated poly(vinyl alc.)-wrapped ...

2011

X-ray structures of general anaesthetics bound to a pentameric ligand-gated ion channel

General anaesthetics have enjoyed long and widespread use but their molecular mechanism of action remains poorly understood. There is good evidence that their principal targets are pentameric ligand-gated ion channels (pLGICs) such as inhibitory GABA(A) (γ ...

Nature Publishing Group2011

Encapsulation of Pyrene-Functionalized Poly(benzyl ether) Dendrons into a Water-Soluble Organometallic Cage

Olivier Pierre Zava

Two generations of lipophilic pyrenyl functionalized poly(benzyl ether) dendrimers (P-1 and P-2) have been synthesized. The thermal properties of the two functionalized dendrimers have been investigated, and the pyrenyl group of the dendritic molecules enc ...

2011

Flexible antibodies with nonprotein hinges

Florian Maria Wurm

There is a significant need for antibodies that can bind targets with greater affinity. Here we describe a. novel strategy employing chemical semisynthesis to produce symmetroadhesins: antibody-like molecules having nonprotein hinge regions that are more f ...

2011

Double targeting of tumours with pyrenyl-modified dendrimers encapsulated in an arene-ruthenium metalla-prism

Paul Joseph Dyson, Olivier Pierre Zava

The self-assembly of 2,4,6-tris(pyridin-4-yl)-1,3,5-triazine (tpt) triangular panels with p-cymene ruthenium building blocks and 5,8-dioxido-1,4-naphthoquinonato (donq) bridges, in the presence of pyrenyl-containing dendrimers of different generations (P-0 ...

2011

Transduction of Glycan-Lectin Binding Using Near-Infrared Fluorescent Single-Walled Carbon Nanotubes for Glycan Profiling

Ardemis Anoush Boghossian

There is significant interest in developing new detection platforms for characterizing glycosylated proteins, despite the lack of easily synthesized model glycans or high affinity receptors for this anal. problem. In this work, the authors demonstrate a se ...

2011

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