Publications related to Animal drug

Lansoprazole is an antituberculous prodrug targeting cytochrome bc1

Stewart Cole, Florence Pojer, Claudia Sala, Andrej Benjak, Anthony Vocat, Philippe Busso, Jan Lars Rybniker

Better antibiotics capable of killing multi-drug-resistant Mycobacterium tuberculosis are urgently needed. Despite extensive drug discovery efforts, only a few promising candidates are on the horizon and alternative screening protocols are required. Here, ...

Nature Publishing Group2015

Preclinical combination therapy of the investigational drug NAMI-A(+) with doxorubicin for mammary cancer

Paul Joseph Dyson, Tina Riedel, Gianni Sava

Aim of the study The tumor metastases targeting ruthenium complex NAMI-A synergistically improves the activity of gemcitabine in combination therapies. High-throughput screening was used to identify other potential drug combinations from a library of FDA a ...

Springer2015

The FDA-approved natural product dihydroergocristine reduces the production of the Alzheimer's disease amyloid-beta peptides

Patrick Fraering, Jianhua Liu, Jing Yu

Known gamma-secretase inhibitors or modulators display an undesirable pharmacokinetic profile and toxicity and have therefore not been successful in clinical trials for Alzheimer's disease (AD). So far, no compounds from natural products have been identifi ...

Nature Publishing Group2015

Novel therapeutic strategy for neurodegeneration by blocking Aβ seeding mediated aggregation in models of Alzheimer's disease

Hilal Lashuel, Patrick Fraering, Saviana Di Giovanni, Simona Eleuteri

Aβ accumulation plays a central role in the pathogenesis of Alzheimer's disease (AD). Recent studies suggest that the process of Aβ nucleated polymerization is essential for Aβ fibril formation, pathology spreading and toxicity. Therefore, targeting this p ...

2015

Automated multi-parameter measurement of cardiomyocytes dynamics with digital holographic microscopy

Gerardo Turcatti, Benjamin Rappaz, Pierre Marquet

Compounds tested during drug development may have adverse effects on the heart; therefore all new chemical entities have to undergo extensive preclinical assessment for cardiac liability. Conventional intensity-based imaging techniques are not robust enoug ...

Optical Society of America2015

A Simple Model for Testing Drugs against Non-replicating Mycobacterium tuberculosis

Stewart Cole, Neeraj Dhar, Claudia Sala, Ruben Hartkoorn, Ming Zhang

Non-replicating or dormant cells of Mycobacterium tuberculosis constitute a challenge to tuberculosis (TB) therapy because of their tolerance or phenotypic resistance to most drugs. Here, we propose a simple model for testing drugs against non-growing cell ...

2010

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Animal drug

Lansoprazole is an antituberculous prodrug targeting cytochrome bc1

Preclinical combination therapy of the investigational drug NAMI-A(+) with doxorubicin for mammary cancer

The FDA-approved natural product dihydroergocristine reduces the production of the Alzheimer's disease amyloid-beta peptides

Novel therapeutic strategy for neurodegeneration by blocking Aβ seeding mediated aggregation in models of Alzheimer's disease

Automated multi-parameter measurement of cardiomyocytes dynamics with digital holographic microscopy

A Simple Model for Testing Drugs against Non-replicating Mycobacterium tuberculosis

Nostocarboline: isolation and synthesis of a new cholinesterase inhibitor from Nostoc 78-12A

A gene therapy approach to regulated delivery of erythropoietin as a function of oxygen tension

Graph Chatbot

Chat with Graph Search

Novel therapeutic strategy for neurodegeneration by blocking Aβ seeding mediated aggregation in models of Alzheimer's disease

A Simple Model for Testing Drugs against Non-replicating Mycobacterium tuberculosis

Automated multi-parameter measurement of cardiomyocytes dynamics with digital holographic microscopy

Nostocarboline: isolation and synthesis of a new cholinesterase inhibitor from Nostoc 78-12A

The FDA-approved natural product dihydroergocristine reduces the production of the Alzheimer's disease amyloid-beta peptides

Lansoprazole is an antituberculous prodrug targeting cytochrome bc1

A gene therapy approach to regulated delivery of erythropoietin as a function of oxygen tension

Preclinical combination therapy of the investigational drug NAMI-A(+) with doxorubicin for mammary cancer