Concept

Plant cell

Related publications (297)

Memory and relatedness of transcriptional activity in mammalian cell lineages

Felix Naef, David Michael Suter, Nicholas Edward Phillips, Aleksandra Mandic, Saeed Omidi Klishami

Phenotypically identical mammalian cells often display considerable variability in transcript levels of individual genes. How transcriptional activity propagates in cell lineages, and how this varies across genes is poorly understood. Here we combine live- ...

2019

Peptide Targeting of an Intracellular Receptor of the Secretory Pathway

Pablo Rivera Fuentes

Numerous peptides serve as natural ligands of intra- and extracellular receptors. The presence of charged amino acids, however, often hinders the membrane-crossing ability of some of these peptides and renders them unsuitable as chem. probes for perturbing ...

2019

A molecular logic gate enables super-resolved imaging of intracellular lipid droplets

Pablo Rivera Fuentes, Adam Miklos Eördögh

Photoactivatable dyes enable single-mol. imaging in biol. Despite progress in the development of new fluorophores and labeling strategies, many cellular compartments remain difficult to image beyond the limit of diffraction in living cells. For example, li ...

2019

A Coumarin Triflate Reagent Enables One‐Step Synthesis of Photo‐Caged Lipid Metabolites for Studying Cell Signaling

Milena Maria Schuhmacher

Photorelease of caged compounds is among the most powerful experimental approaches for studying cellular functions on fast timescales. However, its full potential has yet to be exploited, as the number of caged small molecules available for cell biological ...

2019

Selective Localization of Hierarchically Assembled Particles to Plasma Membranes of Living Cells

Francesco Stellacci, Randy Patrick Carney

Particles that preferentially partition to a specific cellular subunit, such as the nucleus, mitochondria, or the cytoskeleton, are of relevance to a number of applications, including drug delivery, genetic manipulation, or self-assembly. Here, hierarchica ...

WILEY-V C H VERLAG GMBH2019

Cyclodextrin triggers MCOLN1-dependent endo-lysosome secretion in Niemann-Pick type C cells[S]

Jonathan Paz Montoya, Marc Moniatte

In specialized cell types, lysosome-related organelles support regulated secretory pathways, whereas in nonspecialized cells, lysosomes can undergo fusion with the plasma membrane in response to a transient rise in cytosolic calcium. Recent evidence also i ...

2019

Kinetic models of metabolism that consider alternative steady-state solutions of intracellular fluxes and concentrations

Vassily Hatzimanikatis, Ljubisa Miskovic, Meriç Ataman, Georgios Fengos, Tuure Eelis Hameri

Large-scale kinetic models are used for designing, predicting, and understanding the metabolic responses of living cells. Kinetic models are particularly attractive for the biosynthesis of target molecules in cells as they are typically better than other t ...

2019

Small-Molecule Fluorescent Probes for Live-Cell Super-Resolution Microscopy

Kai Johnsson, Lu Wang, Aleksandar Salim, Michelle Susanne Frei

Super-resolution fluorescence microscopy is a powerful tool to visualize biomolecules and cellular structures at the nanometer scale. Employing these techniques in living cells has opened up the possibility to study dynamic processes with unprecedented spa ...

AMER CHEMICAL SOC2019

Endogenous fluctuations of OCT 4 and SOX 2 bias pluripotent cell fate decisions

David Michael Suter, Cédric Deluz, Torgil Elias Friman, Andrea Brigitta Alber, Subashika Govindan, Daniel Strebinger

SOX2 and OCT4 are pioneer transcription factors playing a key role in embryonic stem (ES) cell self‐renewal and differentiation. How temporal fluctuations in their expression levels bias lineage commitment is unknown. Here, we generated knock‐in reporter f ...

2019

Fabrication and characterization of silicone-based dielectric elastomer actuators for mechanical stimulation of living cells

Herbert Shea, Samuel Rosset, Alexandre Poulin

Cellular biology is a promising field of application for dielectric elastomer actuators (DEAs) given that large strains are needed but only low forces are required. The development of devices compatible with standard cell culture protocols and equipment is ...

2018

Graph Chatbot

Chat with Graph Search

Ask any question about EPFL courses, lectures, exercises, research, news, etc. or try the example questions below.

DISCLAIMER: The Graph Chatbot is not programmed to provide explicit or categorical answers to your questions. Rather, it transforms your questions into API requests that are distributed across the various IT services officially administered by EPFL. Its purpose is solely to collect and recommend relevant references to content that you can explore to help you answer your questions.