Publications related to Peptide hormone

Peptide-Hypervalent Iodine Reagent Chimeras: Enabling Peptide Functionalization and Macrocyclization

Jérôme Waser, Christian Heinis, Xinjian Ji, Xingyu Liu

Herein, we report a novel strategy for the modification of peptides based on the introduction of highly reactive hypervalent iodine reagents-ethynylbenziodoxolones (EBXs)-onto peptides. These peptide-EBXs can be readily accessed, by both solution- and soli ...

WILEY-V C H VERLAG GMBH2023

Single-Molecule Peptide Identification Using Fluorescence Blinking Fingerprints

Pablo Rivera Fuentes, Salome Riccarda Püntener

The ability to identify peptides with single-molecule sensitivity would lead to next-generation proteomics methods for basic research and clinical applications. Existing single-molecule peptide sequencing methods can read some amino acid sequences, but the ...

AMER CHEMICAL SOC2023

Islet Encapsulation: New Developments for the Treatment of Type 1 Diabetes

Sandrine Gerber, Qixing Zhang, Yi Wang, Léo Bühler

Islet transplantation is a promising approach for the treatment of type 1 diabetes (T1D). Currently, clinical islet transplantation is limited by allo - and autoimmunity that may cause partial or complete loss of islet function within a short period of tim ...

2022

Hypervalent Iodine-Mediated Late-Stage Peptide and Protein Functionalization

Jérôme Waser, Elija Grinhagena, Emmanuelle Madeline Dominique Allouche

Hypervalent iodine compounds are powerful reagents for the development of novel transformations. As they exhibit low toxicity, high functional group tolerance, and stability in biocompatible media, they have been used for the functionalization of biomolecu ...

WILEY-V C H VERLAG GMBH2021

A minimalistic cyclic ice-binding peptide from phage display

Harm-Anton Klok, Luciano Andres Abriata, Corey Alfred Stevens, Matthew Gibson, Xudong Kong

Developing molecules that emulate the properties of naturally occurring ice-binding proteins (IBPs) is a daunting challenge. Rather than relying on the (limited) existing structure–property relationships that have been established for IBPs, here we report ...

2021

Variably Scaled Kernels Improve Classification of Hormonally-Treated Patient-Derived Xenografts

Cathrin Brisken, Fabio De Martino, Marie Shamseddin, Francesco Marchetti

Little is known about the biological functions which are exerted by hormone receptors in physiological conditions. Here, we made use of the Mouse INtraDuctal (MIND) model, an innovative patient-derived xenograft (PDX) model, to characterize global gene exp ...

IEEE2020

De novo development of proteolytically resistant therapeutic peptides for oral administration

Christian Heinis, Luciano Andres Abriata, Florence Pojer, Xudong Kong, Vanessa Carle, Jun Moriya

The oral administration of peptide drugs is hampered by their metabolic instability and limited intestinal uptake. Here, we describe a method for the generation of small target-specific peptides (less than 1,600 Da in size) that resist gastrointestinal pro ...

2020

What is the 'spectral diet' of humans?

Marilyne Andersen, Forrest Simon Webler, Manuel Spitschan

Our visual perception of the world - seeing form and colour or navigating the environment - depends on the interaction of light and matter in the environment. Light also has a more fundamental role in regulating rhythms in physiology and behaviour, as well ...

ELSEVIER2019

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Peptide hormone

Method for hormone or drug screening in a tissue sample

Peptide-Hypervalent Iodine Reagent Chimeras: Enabling Peptide Functionalization and Macrocyclization

Single-Molecule Peptide Identification Using Fluorescence Blinking Fingerprints

Islet Encapsulation: New Developments for the Treatment of Type 1 Diabetes

Hypervalent Iodine-Mediated Late-Stage Peptide and Protein Functionalization

A minimalistic cyclic ice-binding peptide from phage display

Variably Scaled Kernels Improve Classification of Hormonally-Treated Patient-Derived Xenografts

De novo development of proteolytically resistant therapeutic peptides for oral administration

In pancreatic islets from type 2 diabetes patients, the dampened circadian oscillators lead to reduced insulin and glucagon exocytosis

What is the 'spectral diet' of humans?

Graph Chatbot

Chat with Graph Search

Method for hormone or drug screening in a tissue sample

In pancreatic islets from type 2 diabetes patients, the dampened circadian oscillators lead to reduced insulin and glucagon exocytosis

Hypervalent Iodine-Mediated Late-Stage Peptide and Protein Functionalization

A minimalistic cyclic ice-binding peptide from phage display

De novo development of proteolytically resistant therapeutic peptides for oral administration

Peptide-Hypervalent Iodine Reagent Chimeras: Enabling Peptide Functionalization and Macrocyclization

What is the 'spectral diet' of humans?

Single-Molecule Peptide Identification Using Fluorescence Blinking Fingerprints

Islet Encapsulation: New Developments for the Treatment of Type 1 Diabetes

Variably Scaled Kernels Improve Classification of Hormonally-Treated Patient-Derived Xenografts