Concept

Keto acid

Related publications (32)

Infrared spectroscopy of hydrated amino acids in the gas phase: protonated and lithiated valine

Thomas Rizzo, Rainer Beck, Sébastien Mercier, Evan Rowland Williams

We report here infrared spectra of protonated and lithiated valine with varying degrees of hydration in the gas phase and interpret them with the help of DFT calculations at the B3LYP/6-31++G** level. In both the protonated and lithiated species, our resul ...

2006

Synthesis of ring-A-substituted tryptophan by a palladium-catalyzed heteroannulation reaction

Jieping Zhu

Coupling of substituted 2-iodoanilines with Me (S)-2-[di(tert-butoxycarbonyl)amino]-5-oxopentanoate, derived from glutamic acid, in DMF in the presence of Pd(OAc)2 and DABCO provides substituted tryptophans in good to excellent yields. [on SciFinder (R)] ...

2005

Introduction of hydroxyl- or keto- functionalities into the side chain of azetidin-2-ones via allylic bromide rearrangement, followed by supported reagent substitution

Fides Benfatti

This paper reports the allylic bromide rearrangement of 3-bromo-3-alkenyl-azetidin-2-ones, induced by m-chloroperbenzoic acid, N-bromosuccinimide or benzoylperoxide as radical initiators. The substitution of bromide by resin supported acids, followed by hy ...

2005

Chlorination of natural organic matter: kinetics of chlorination and of THM formation

Urs von Gunten

The kinetics of the formation of trihalomethanes (THMs) and of chlorine consumption for the chlorination of natural organic matter with an excess of chlorine (50 muM > Cl-2 > 210 muM) was investigated. THM precursors could be divided into a fast and a ...

2002

Synthesis of β-hexa- and β-heptapeptides containing novel β2,3-amino acids with two serine or two cysteine side chains - CD- and NMR-spectroscopic evidence for 314-helical secondary structures in water

Karl Gademann

Two representatives of a new type of beta-amino acids, carrying two functionalized side chains, one in the 2- and one in the 3-position, have been prepd. stereoselectively: a beta-Ser deriv. with an addnl. CH2OH group in the 2-position, for beta-peptides w ...

2000

Synthesis and biological evaluation of a cyclo-β-tetrapeptide as a somatostatin analog

Karl Gademann

Cyclo-beta-tetrapeptide I, a beta-peptidic analog of octreotide, was prepd. from beta-amino acid building blocks synthesized by Arndt-Eistert homologation of appropriately protected alpha-amino acids. The affinity of I for five different human somatostatin ...

1999

Linear and cyclic β3-oligopeptides with functionalized side-chains (-CH2OBn, -CO2Bn, -CH2CH2CO2Bn) derived from serine and from aspartic and glutamic acid

Karl Gademann

The natural beta-amino acid deriv. Boc-Asp-OBn (Boc = Me3CO2C; Bn = CH2Ph), as well as I (R = CH2CH2CO2Bn, CH2OBn; TCE = CH2CCl3) (prepd. from appropriately protected glutamic acid and serine, resp., by Arndt-Eistert homologation), were employed as buildin ...

1998

β(2)- and β(3)-peptides with proteinaceous side-chains. Synthesis and solution structures of constitutional isomers, a novel helical secondary structure, and the influence of solvation and hydrophobic interactions on folding

Karl Gademann

Enantiomerically pure beta-amino acid derivs. with the side-chains of Ala, Val, and Leu in the 2- or 3-position (β2- and β3-amino acids, resp.), as well as with substituents in both the 2- and 3-positions (β2,3-amino acids, of like-configuration) were prep ...

1998

Oligomerization properties of GCN4 leucine zipper e and g position mutants

Hilal Lashuel, Xi Zeng

Putative intersubunit electrostatic interactions between charged amino acids on the surfaces of the dimer interfaces of leucine zippers (g-e' ion pairs) have been implicated as determinants of dimerization specificity. To evaluate the importance of these i ...

Cold Spring Harbor Laboratory Press1997

"Mixed" β-peptides. A unique helical secondary structure in solution. Preliminary communication

Karl Gademann

beta-Hexapeptides and a beta-dodecapeptide with sequences contg. two different types of beta-amino acids, aliph. proteinaceous side-chains in 2- or 3-position, were studied with CD and NMR measurements. With one exception, the secondary structures formed b ...

1997

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