A lipid profile or lipid panel is a panel of blood tests used to find abnormalities in lipids, such as cholesterol and triglycerides. The results of this test can identify certain genetic diseases and can determine approximate risks for cardiovascular disease, certain forms of pancreatitis, and other diseases.
Lipid panels are usually ordered as part of a physical exam, along with other panels such as the complete blood count (CBC) and basic metabolic panel (BMP).
The lipid profile typically includes:
Low-density lipoprotein (LDL)
High-density lipoprotein (HDL)
Triglycerides
Total cholesterol
Using these values, a laboratory may also calculate:
Very low-density lipoprotein (VLDL)
Cholesterol:HDL ratio
The lipid profile tests are of 7 types:
Total lipids
Serum total cholesterol
serum HDL cholesterol
Total cholesterol/HDL cholesterol ratio
Serum triglycerides
Serum Phospholipids
Electrophoretic fractionation to determination percentage of
(a) Chylomicrons
(b) LDL
(c) VLDL
(d) HDL
Recommendations for cholesterol testing come from the Adult Treatment Panel (ATP) III guidelines, and are based on many large clinical studies, such as the Framingham Heart Study.
For healthy adults with no cardiovascular risk factors, the ATP III guidelines recommend screening once every five years. A lipid profile may also be ordered at regular intervals to evaluate the success of lipid-lowering drugs such as statins.
In the pediatric and adolescent population, lipid testing is not routinely performed. However, the American Academy of Pediatrics and the National Heart, Lung, and Blood Institute (NHLBI) recommend that children aged 9–11 be screened once for severe cholesterol abnormalities. This screening can be valuable to detect genetic diseases such as familial hypercholesterolemia that can be lethal if not treated early.
Traditionally, most laboratories have required patients to fast for 9–12 hours before screening. However, studies have questioned the utility of fasting before lipid panels, and some diagnostic labs routinely accept non-fasting samples.
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Le but est de connaitre et comprendre le fonctionnement des systèmes cardiovasculaire, urinaire, respiratoire, digestif, ainsi que du métabolisme de base et sa régulation afin de déveloper une réflect
Lysosomal acid lipase deficiency (LAL deficiency or LAL-D) is an autosomal recessive inborn error of metabolism that results in the body not producing enough active lysosomal acid lipase (LAL) enzyme. This enzyme plays an important role in breaking down fatty material (cholesteryl esters and triglycerides) in the body. Infants, children and adults that have LAL deficiency experience a range of serious health problems.
Hyperlipidemia is abnormally elevated levels of any or all lipids (fats, cholesterol, or triglycerides) or lipoproteins in the blood. The term hyperlipidemia refers to the laboratory finding itself and is also used as an umbrella term covering any of various acquired or genetic disorders that result in that finding. Hyperlipidemia represents a subset of dyslipidemia and a superset of hypercholesterolemia. Hyperlipidemia is usually chronic and requires ongoing medication to control blood lipid levels.
Familial hypercholesterolemia (FH) is a genetic disorder characterized by high cholesterol levels, specifically very high levels of low-density lipoprotein cholesterol (LDL cholesterol), in the blood and early cardiovascular diseases. The most common mutations diminish the number of functional LDL receptors in the liver or produce abnormal LDL receptors that never go to the cell surface to function properly (abnormal trafficking).
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