Laboratory of Integrative Systems Physiology

The Laboratory of Integrative and Systemic Physiology at EPFL, led by Professor Johan Auwerx, focuses on mapping the signaling networks that govern mitochondrial function and regulate organismal metabolism. Their research has led to the development of new methodologies and scientific approaches applied to various model systems, including humans, to understand how signaling pathways control mitochondrial function and metabolism. The lab emphasizes innovation and translational research, aiming to translate their findings into novel preventive and therapeutic strategies for common diseases like type 2 diabetes, frailty, and obesity, as well as rare inherited mitochondrial diseases. Their work has successfully collaborated with the biopharmaceutical industry, leading to the development of drugs targeting processes and pathways elucidated by the lab.