Concept

Translation (biology)

Related publications (120)

Bicaudal C1 promotes pancreatic NEUROG3+ endocrine progenitor differentiation and ductal morphogenesis

Mutations in Bicaudal C1 (BICC1), an RNA binding protein involved in translational regulation, have been associated with cystic kidney disease both in humans and in mice. Since kidney cysts associate with pancreatic defects in several human syndromes, we i ...

EPFL2015

Tetracycline Antibiotics Impair Mitochondrial Function and Its Experimental Use Confounds Research

Johan Auwerx, Laurent Mouchiroud, Richardus Houtkooper

Tetracyclines, a class of antibiotics that target bacterial translation, are commonly used in research for inducible gene expression using Tet-ON/Tet-OFF systems. However, such tetracycline-inducible systems carry a risk. Given that mitochondria have a "ba ...

American Association for Cancer Research2015

Translational arrest by a prokaryotic signal recognition particle is mediated by RNA interactions

Henning Paul-Julius Stahlberg

The signal recognition particle (SRP) recognizes signal sequences of nascent polypeptides and targets ribosome-nascent chain complexes to membrane translocation sites. In eukaryotes, translating ribosomes are slowed down by the Alu domain of SRP to allow e ...

Springer Nature2015

Circadian and feeding rhythms differentially affect rhythmic mRNA transcription and translation in mouse liver

Felix Naef, Cédric Gobet, Patrick Descombes, Frédéric Bruno Martin Gachon, Benjamin Dieter Weger, Jingkui Wang, Florian Atger

Diurnal oscillations of gene expression are a hallmark of rhythmic physiology across most living organisms. Such oscillations are controlled by the interplay between the circadian clock and feeding rhythms. Although rhythmic mRNA accumulation has been exte ...

National Academy of Sciences2015

Bicc1 Polymerization Regulates the Localization and Silencing of Bound mRNA

Daniel Constam, Benjamin Marcel Daniel Rothé, Lucía Carolina Leal Esteban, Séverine Marguerite Urfer, Florian Urs Bernet

Loss of the RNA-binding protein Bicaudal-C (Bicc1) provokes renal and pancreatic cysts as well as ectopic Wnt/beta-catenin signaling during visceral left-right patterning. Renal cysts are linked to defective silencing of Bicc1 target mRNAs, including adeny ...

American Society for Microbiology2015

Mind the Gap? Translating science and technology projects with TED

Gianluigi Viscusi, Heidi Christina Gautschi

The term ‘translational research’ appeared in Pubmed for the first time around 1993 (van der Laan & Boenink, 2012). Translational research aims to identify and challenge the “translational gaps’’ (T gaps) hindering the transformation of discoveries in the ...

2015

Translating innovation with information infrastructures: the case of TED as a valuation device

Gianluigi Viscusi, Heidi Christina Gautschi

This article aims to investigate the TED infrastructure for translating Science and Technology (S&T) projects (Callon, 1981, 1986; Law, 2006). The analysis uses the concepts of recognition (Honneth, 2012) and the public sphere as interpretative lenses for ...

2015

A Dual Program for Translation Regulation in Cellular Proliferation and Differentiation

Sebastian Martin Waszak

A dichotomous choice for metazoan cells is between proliferation and differentiation. Measuring tRNA pools in various cell types, we found two distinct subsets, one that is induced in proliferating cells, and repressed otherwise, and another with the oppos ...

Cell Press2014

Circadian clock-dependent and -independent rhythmic proteomes implement distinct diurnal functions in mouse liver

Felix Naef, Frédéric Bruno Martin Gachon, Daniel Alain Dominique Marie Mauvoisin, Jingkui Wang, Florian Atger, Celine Jouffe

Diurnal oscillations of gene expression controlled by the circadian clock underlie rhythmic physiology across most living organisms. Although such rhythms have been extensively studied at the level of transcription and mRNA accumulation, little is known ab ...

Natl Acad Sciences2014

Crystals of Bound States in the Magnetization Plateaus of the Shastry-Sutherland Model

Frédéric Mila

Using infinite projected entangled-pair states, we show that the Shastry-Sutherland model in an external magnetic field has low-magnetization plateaus which, in contrast to previous predictions, correspond to crystals of bound states of triplets, and not t ...

2014

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