Concept

Detoxification

Related publications (21)

Hepatic glucose sensing and integrative pathways in the liver

Kristina Schoonjans, Maaike Hélène Oosterveer

The hepatic glucose-sensing system is a functional network of enzymes and transcription factors that is critical for the maintenance of energy homeostasis and systemic glycemia. Here we review the recent literature on its components and metabolic actions. ...

Springer Basel Ag2014

Accumulation of pollutants and plant wellness: bottleneck or key to a successful phytoremediation?

Jean-Paul Schwitzguebel

Plants have efficient mechanisms for detoxification and sequestration of xenobiotic chemicals and trace elements, basis of any efficient phytoremediation process. However the amount of pollutants that can be accumulated and detoxified without disrupting th ...

2012

Mathematical Modeling of Brain Energy Metabolism, Measured with PET and MRS in Rodents

Bernard Lanz

Positron emission tomography (PET) and nuclear magnetic resonance spectroscopy (MRS) are two biomedical measurement techniques developed in the end of the XXth century, which drastically improved the amount of accessible information available in vivo. PET ...

EPFL2012

Accumulation of pollutants and plant wellness : Bottleneck or key to successful phytoremediation ?

Jean-Paul Schwitzguebel

Because plants are static and live in a competitive and sometimes hostile environment, they have evolved mechanisms that protect them from abiotic and biotic stress. These mechanisms include detoxification and sequestration of xenobiotic compounds and of h ...

2011

Plant accumulation of pollutants versus plant wellness: insoluble conundrum or key to a successful green clean-up?

Jean-Paul Schwitzguebel

2010

Accumulation and transoformation of sulfonated aromatic compounds by higher plants - toward the phytotreatment of wastewater from dye and textile industries

Jean-Paul Schwitzguebel, Sylvie Aubert, Stéphanie Braillard

Sulfonated anthraquinones are precursors of many synthetic dyes and pigments, recalcitrant to biodegradation and thus not eliminated by classical wastewater treatments. In the development of a phytoremediation process to remove sulfonated aromatic compound ...

Springer-Verlag2008

The possible role of hydroxylation in the detoxification of atrazine in mature vetiver (Chrysopogon zizanioides nash) grown in hydroponics

Jean-Paul Schwitzguebel, Sylvie Vullioud-Marcacci

The resistance mechanism of vetiver (Chrysopogon zizanioides) to atrazine was investigated to evaluate its potential for phytoremediation of environment contaminated with the herbicide. Plants known to metabolise atrazinerely on hydroxylation mediated by b ...

2005

Treatment of acetaminophen-induced acute liver failure in the mouse with conditionally immortalized human hepatocytes

Didier Trono

BACKGROUND/AIMS: Liver failure is a life threatening condition currently treated by palliative measures and, when applicable, organ transplantation. The use of a bioartificial organ capable of fulfilling the main functions of the liver would represent an a ...

Elsevier2005

Long-term modulation of glucose utilization by IL-1 alpha and TNF-alpha in astrocytes: Na+ pump activity as a potential target via distinct signaling mechanisms

Pierre Magistretti, Luc Pellerin

Interleukin-1alpha (IL-1alpha) and tumor necrosis factor-alpha (TNF-alpha) markedly stimulate glucose utilization in primary cultures of mouse cortical astrocytes. The mechanism that gives rise to this effect, which takes place several hours after applicat ...

2002

Glutamate uptake into astrocytes stimulates aerobic glycolysis: a mechanism coupling neuronal activity to glucose utilization

Pierre Magistretti, Luc Pellerin

Glutamate, released at a majority of excitatory synapses in the central nervous system, depolarizes neurons by acting at specific receptors. Its action is terminated by removal from the synaptic cleft mostly via Na(+)-dependent uptake systems located on bo ...

1994

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