Concept

Cell division

Related publications (464)

Post-translational regulation enables robust p53 regulation

The tumor suppressor protein p53 plays important roles in DNA damage repair, cell cycle arrest and apoptosis. Due to its critical functions, the level of p53 is tightly regulated by a negative feedback mechanism to increase its tolerance towards fluctuatio ...

BioMed Central2013

Mechanisms of spindle positioning: cortical force generators in the limelight

Pierre Gönczy, Sachin Kotak

Correct positioning of the spindle governs placement of the cytokinesis furrow and thus plays a crucial role in the partitioning of fate determinants and the disposition of daughter cells in a tissue. Converging evidence indicates that spindle positioning ...

2013

Mechanisms of spindle positioning: cortical force generators in the limelight

Pierre Gönczy, Sachin Kotak

2013

Monitoring proliferative activities of hormone-like odorants in human breast cancer cells by gene transcription profiling and electrical impedance spectroscopy

Horst Vogel, Cathrin Brisken, Horst Pick, Samuel Terrettaz, Olivia Baud

The human estrogen receptor alpha (ER!) mediates the proliferative action of hormones in breast cancer cells by regulating the expression of target genes to control cellular functions. Current methodologies do not permit a real-time assessment of these pro ...

Elsevier2013

Structure of the Dodecameric Yersinia enterocolitica Secretin YscC and Its Trypsin-Resistant Core

Henning Paul-Julius Stahlberg, Andreas Engel

The type Ill secretion system machinery, also known as the injectisome, delivers bacterial effector proteins into eukaryotic cells during infection. The outer membrane YscC secretin is a major part of Yersinia enterocolitica's injectisome and is among the ...

Elsevier BV2013

The physics and micro-mechanics of nano-voids and nano-particles in polymer combinations

In this article the role of voids or particulate inclusions of different sizes on mechanical properties and particularly on toughness in several polymers is discussed. With decreasing void sizes and intervoid distances, the influence of the interphase mate ...

Elsevier Sci Ltd2013

The Mucosal Adjuvant Cholera Toxin B Instructs Non-Mucosal Dendritic Cells to Promote IgA Production Via Retinoic Acid and TGF-β

Nicola Harris

It is currently unknown how mucosal adjuvants cause induction of secretory immunoglobulin A (IgA), and how T cell-dependent (TD) or -independent (TI) pathways might be involved. Mucosal dendritic cells (DCs) are the primary antigen presenting cells driving ...

Public Library of Science2013

A Quantitative Telomeric Chromatin Isolation Protocol (Q-TIP) to Characterize Telomere Composition Changes

Larissa Grolimund

Telomeres protect linear ends of eukaryotic chromosomes by preventing chromosomal end-to-end fusions and telomere attrition. They consist of repetitive DNA sequences, telomeric repeat containing RNAs (TERRAs) and proteins. Telomeres play a crucial role in ...

EPFL2013

Single-cell lysis for visual analysis by electron microscopy

Henning Paul-Julius Stahlberg

The stochastic nature of biological systems makes the study of individual cells a necessity in systems biology. Yet, handling and disruption of single cells and the analysis of the relatively low concentrations of their protein components still challenges ...

Elsevier BV2013

Mycobacterium tuberculosis EspB binds phospholipids and mediates EsxA-independent virulence

Stewart Cole, Neeraj Dhar, Florence Pojer, Stefanie Boy-Röttger, Ming Zhang, Jan Lars Rybniker, Jeffrey Chen

The type-VII ESX-1 secretion apparatus, encoded by the esx-1 genetic locus, is essential for the export of EsxA and EsxB, two major virulence factors of Mycobacterium tuberculosis. ESX-1 also requires the products of the unlinked espACD operon for optimal ...

Wiley-Blackwell2013

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