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Carbon-carbon bond forming reactions are among the most important and useful methods for organic synthesis. During the last years, significant progress has been made in this field. Whereas many catalysts were developed for the coupling of aryl, alkenyl, an ...
The cyclopentadienyl Ru complexes CpRuCl(cod) (cod = 1,5-cyclooctadiene), CpRuCl(PPh3)2, and [CpRuCl2]2 (Cp = η5-1-methoxy-2,4-di-tert-butyl-3-neopentylcyclopentadienyl) are able to catalyze the decomposition of benzyl azides to give 1,3,5-triphenyl-2,4- ...
The first ene reactions of SO2 and unfunctionalized alkenes are reported. Calculations suggest that the endergonic ene reactions of SO2 with alkenes can be used to generate beta,gamma-unsaturated sulfinyl and sulfonyl compounds. Indeed, in the presence of ...
The bifunctional catalyst 6'-deoxy-6'-acylamino-beta -isocupreidine served both as a base to trigger the in situ generation of N-sulfonylimine from readily available alpha -amidosulfones and as a chiral nucleophile to initiate the enantioselective aza-Mori ...
An approach to the synthesis of polyhydroxyazepane derivatives from sugar-based epoxyamides or epoxyalcohols, in which the total regioselective epoxide opening by nitrogen nucleophiles is the key step, is described. Thus, novel polyhydroxyazepane carboxami ...
Cyclopentadienyl-ruthenium half-sandwich complexes with 2-bound alkyne ligands have been suggested as catalytic intermediates in the early stages of Ru-catalyzed reactions with alkynes. We show that electronically unsaturated complexes of the formula [RuCl ...
Ribonuclease H (RNase H) belongs to the nucleotidyl-transferase superfamily and hydrolyzes the phosphodiester linkage on the RNA strand of a DNA/RNA hybrid duplex. Due to its activity in HIV reverse transcription, it represents a promising target for anti- ...
The reaction of tetranitromethane with B-alkylcatecholboranes leads to the formation of unusual dinitrooxime ethers. A tentative mechanism is provided, which suggests the involvement of extremely fast addition of alkyl radicals to tetranitromethane. The su ...
Functional groups are prerequisites for the assembly of building blocks to more elaborate structures for research work in the life sciences field. Functionalization can be most conveniently and efficaciously accomplished by generating an organometallic der ...
Reaction of aldehydes, anilines, and enecarbamates in dichloromethane in the presence of EtOH and a catalytic amt. of chiral phosphoric acid I afforded the Mannich adducts which were in situ reduced to anti-1,2-disubstituted 1,3-diamines II in excellent di ...