Concept

Growth cone

Related publications (65)

Neurogenesis redirects β-catenin from adherens junctions to the nucleus to promote axonal growth

Here, we show that, in the developing spinal cord, after the early Wnt-mediated Tcf transcription activation that confers dorsal identity to neural stem cells, neurogenesis redirects beta-catenin from the adherens junctions to the nucleus to stimulate Tcfo ...

Cambridge2023

Spinal cord injury (SCI) interrupts axonal connections between the brain and the spinal cord, and is characterized by a spectrum of sensorimotor and autonomic impairments. While spontaneous recovery is limited, recent studies have shown that functional imp ...

EPFL2023

The establishment of neuronal circuits requires neurons to develop and maintain appropriate connections with cellular partners in and out the central nervous system. These phenomena include elaboration of dendritic arborization and formation of synaptic co ...

MDPI2021

Elezanumab, a human anti-RGMa monoclonal antibody, promotes neuroprotection, neuroplasticity, and neurorecovery following a thoracic hemicompression spinal cord injury in non-human primates

Grégoire Courtine, Quentin Barraud, Lili Huang, Xiaomeng Zhang

Spinal cord injury (SCI) is a devastating condition characterized by loss of function, secondary to damaged spinal neurons, disrupted axonal connections, and myelin loss. Spontaneous recovery is limited, and there are no approved pharmaceutical treatments ...

ACADEMIC PRESS INC ELSEVIER SCIENCE2021

Methods, systems, and apparatus, including computer programs encoded on a computer storage medium for generating model neurons. In one aspect, a method includes receiving a plurality of descriptions of branches of dendrites of one or more neurons and gener ...

2021

Axonal conduction velocity, which ensures efficient function of the brain network, is related to axon diameter. Noninvasive, in vivo axon diameter estimates can be made with diffusion magnetic resonance imaging, but the technique requires three-dimensional ...

NATL ACAD SCIENCES2020

The Target of Exuberant Projections in Development

Giorgio Innocenti

In addition to neuronal death and elimination of synapses, the production of transient, exuberant axons, and axonal branches is a general phenomenon in development across species and systems. To understand what drives the decision of which axons are mainta ...

2020

Living cells adjust their sensing and migratory machinery in response to changes in their environment. In this work, we show that cells of the social amoeba Dictyostelium discoideum modulate the dynamical state of their actin cytoskeleton in response to an ...

AMER PHYSICAL SOC2020

First human trials involving neuroprosthetic rehabilitation demonstrated recently that significant functional benefits can be achieved with lumbosacral neuromodulation and reorganized spared projections. However, complete spinal cord injuries (SCI) wholly ...

EPFL2019

The endosomal sorting adaptor HD-PTP is required for ephrin-B: EphB signalling in cellular collapse and spinal motor axon guidance

Daniel Eduardo Morales Garza

The signalling output of many transmembrane receptors that mediate cell-cell communication is restricted by the endosomal sorting complex required for transport (ESCRT), but the impact of this machinery on Eph tyrosine kinase receptor function is unknown. ...

2019

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