Publications related to Founder effect

On the importance of skewed offspring distributions and background selection in virus population genetics

Kristen Kay Irwin, Jeffrey David Jensen, Séverine Vuilleumier Varisco, Claudia Bank, Sebastian Matuszewski, Stefan Jean Laurent, Hyunjin Shim, Nicky Louise Ormond

Many features of virus populations make them excellent candidates for population genetic study, including a very high rate of mutation, high levels of nucleotide diversity, exceptionally large census population sizes, and frequent positive selection. Howev ...

Nature Publishing Group2016

The Genomic Signature of Population Reconnection Following Isolation: From Theory to HIV

Amalio Telenti, Jeffrey David Jensen, Séverine Vuilleumier Varisco

Ease of worldwide travel provides increased opportunities for organisms not only to colonize new environments but also to encounter related but diverged populations. Such events of reconnection and secondary contact of previously isolated populations are w ...

Genetics Society of America2015

Characterizing neutral genomic diversity and selection signatures in indigenous populations of Moroccan goats (Capra hircus) using WGS data

Stéphane Joost, Sylvie Stucki, Kevin Leempoel, Pierre Taberlet

Since the time of their domestication, goats (Capra hircus) have evolved in a large variety of locally adapted populations in response to different human and environmental pressures. In the present era, many indigenous populations are threatened with extin ...

2015

On the Prospect of Identifying Adaptive Loci in Recently Bottlenecked Populations

Jeffrey David Jensen

Identifying adaptively important loci in recently bottlenecked populations - be it natural selection acting on a population following the colonization of novel habitats in the wild, or artificial selection during the domestication of a breed - remains a ma ...

Public Library of Science2014

On the transition of genetic differentiation from isolation to panmixia: What we can learn from G(ST) and D

Séverine Vuilleumier Varisco

Population genetic differentiation characterizes the repartition of alleles among populations. It is commonly thought that genetic differentiation measures, such as G(ST) and D, should be near zero when allele frequencies are close to their expected value ...

Elsevier2014

On Detecting Incomplete Soft or Hard Selective Sweeps Using Haplotype Structure

Anna Ferrer Admetlla

We present a new haplotype-based statistic (nS(L)) for detecting both soft and hard sweeps in population genomic data from a single population. We compare our new method with classic single-population haplotype and site frequency spectrum (SFS)-based metho ...

Oxford Univ Press2014

A genome-wide association study of resistance to HIV infection in highly exposed uninfected individuals with hemophilia A

Jacques Fellay, Amalio Telenti

Human genetic variation contributes to differences in susceptibility to HIV-1 infection. To search for novel host resistance factors, we performed a genome-wide association study (GWAS) in hemophilia patients highly exposed to potentially contaminated fact ...

Oxford University Press2013

Inferences of Demography and Selection in an African Population of Drosophila melanogaster

Jeffrey David Jensen

It remains a central problem in population genetics to infer the past action of natural selection, and these inferences pose a challenge because demographic events will also substantially affect patterns of polymorphism and divergence. Thus it is imperativ ...

Genetics Society of America2013

Influence of HLA-C Expression Level on HIV Control

Jacques Fellay

A variant upstream of human leukocyte antigen C (HLA-C) shows the most significant genome-wide effect on HIV control in European Americans and is also associated with the level of HLA-C expression. We characterized the differential cell surface expression ...

American Association for the Advancement of Science2013

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Founder effect

On the importance of skewed offspring distributions and background selection in virus population genetics

The Genomic Signature of Population Reconnection Following Isolation: From Theory to HIV

Catch Me if You Can: Adaptation from Standing Genetic Variation to a Moving Phenotypic Optimum

Characterizing neutral genomic diversity and selection signatures in indigenous populations of Moroccan goats (Capra hircus) using WGS data

On the Prospect of Identifying Adaptive Loci in Recently Bottlenecked Populations

On the transition of genetic differentiation from isolation to panmixia: What we can learn from G(ST) and D

On Detecting Incomplete Soft or Hard Selective Sweeps Using Haplotype Structure

A genome-wide association study of resistance to HIV infection in highly exposed uninfected individuals with hemophilia A

Inferences of Demography and Selection in an African Population of Drosophila melanogaster

Influence of HLA-C Expression Level on HIV Control

Graph Chatbot

Chat with Graph Search

Characterizing neutral genomic diversity and selection signatures in indigenous populations of Moroccan goats (Capra hircus) using WGS data

The Genomic Signature of Population Reconnection Following Isolation: From Theory to HIV

A genome-wide association study of resistance to HIV infection in highly exposed uninfected individuals with hemophilia A

Catch Me if You Can: Adaptation from Standing Genetic Variation to a Moving Phenotypic Optimum

Influence of HLA-C Expression Level on HIV Control

On Detecting Incomplete Soft or Hard Selective Sweeps Using Haplotype Structure

On the importance of skewed offspring distributions and background selection in virus population genetics

Inferences of Demography and Selection in an African Population of Drosophila melanogaster

On the transition of genetic differentiation from isolation to panmixia: What we can learn from G(ST) and D

On the Prospect of Identifying Adaptive Loci in Recently Bottlenecked Populations