Concept

Diabetes

Related publications (221)

Definition of in Vitro Microenvironments to Characterize and Control Pancreatic Progenitor Expansion and Differentiation

The pancreas plays a central role in metabolism. The exocrine pancreas, composed of ductal and acinar cells, secretes and delivers digestive enzymes into the duodenum where they contribute to food digestion. The endocrine pancreas, constituted by the islet ...

EPFL2011

Adipocyte NCoR Knockout Decreases PPARγ Phosphorylation and Enhances PPARγ Activity and Insulin Sensitivity

Johan Auwerx, Hiroyasu Yamamoto

Insulin resistance, tissue inflammation, and adipose tissue dysfunction are features of obesity and Type 2 diabetes. We generated adipocyte-specific Nuclear Receptor Corepressor (NCoR) knockout (AKO) mice to investigate the function of NCoR in adipocyte bi ...

2011

JewelPUMP (TM) by Debiotech S.A.: Insulin Temperature Measurement Study

Adrien De Muralt

For type 1 Diabetes, insulin injection therapy is the most used treatment today, and insulin pumps are surely the most accurate therapeutic strategy. The insulin use temperature has to not exceed 37°C to prevent unwanted degradation and loss of function. T ...

2011

Calcareous sponge biomineralization: Ultrastructural and compositional heterogeneity of spicules in Leuconia johnstoni Carter, 1871

Anders Meibom, Jaroslaw Hubert Stolarski, Isabelle Domart-Coulon, Christophe Kopp

In contrast to siliceous sponge spicules, the biomineralization in calcareous sponges is poorly understood. In particular, the existence of a differentiated central core in calcareous spicules is still controversial. Here we combine high-spatial resolution ...

2011

Mitochondrial Matrix Calcium Is an Activating Signal for Hormone Secretion

Kristina Schoonjans, Andreas Wiederkehr, Chikage Mataki

Mitochondrial Ca2+ signals have been proposed to accelerate oxidative metabolism and ATP production to match Ca2+-activated energy-consuming processes. Efforts to understand the signaling role of mitochondrial Ca2+ have been hampered by the inability to ma ...

Elsevier2011

The gait and balance of patients with diabetes can be improved: a randomised controlled trial

Kamiar Aminian, Stéphane Armand

Gait characteristics and balance are altered in diabetic patients. Little is known about possible treatment strategies. This study evaluates the effect of a specific training programme on gait and balance of diabetic patients. ...

2010

Beta amyloid and hyperphosphorylated tau deposits in the pancreas in type 2 diabetes

László Forró, Aleksandra Radenovic, Andras Kis

Strong epidemiologic evidence suggests an association between Alzheimer disease (AD) and type 2 diabetes. To determine if amyloid beta (A

\beta

) and hyperphosphorylated tau occurs in type 2 diabetes, pancreas tissues from 21 autopsy cases (10 type 2 diabe ...

Elsevier2010

Targeting the TGR5-GLP-1 pathway to combat type 2 diabetes and non-alcoholic fatty liver disease

Johan Auwerx, Kristina Schoonjans, Thijs Pols

Incretin-based therapies have shown promise in the treatment of type 2 diabetes. Here we review our current understanding of TGR5 as a target to induce glucagon-like peptide-1 (GLP-1) secretion. These new observations suggest that TGR5 agonists may constit ...

Elsevier Masson2010

Towards high resolution optical imaging of beta cells in vivo

Theo Lasser, Anne Grapin-Botton, Martin Villiger, Joan Goulley, Erica Martin-Williams

Endocrine beta cells produce and release insulin in order to tightly regulate glucose homeostasis and prevent metabolic pathologies such as Diabetes Mellitus. Optical imaging has contributed greatly to our current understanding of beta cell structure and f ...

Bentham Science Publishers2010

Hyperosmolarity enhances transient recombinant protein yield in Chinese hamster ovary cells

Florian Maria Wurm, David Hacker, Lucia Baldi Unser, Xiaowei Zhang, Isabel Fernandez Garcia

The effect of hyperosmolarity on transient recombinant protein production in Chinese hamster ovary (CHO) cells was investigated. Addition of 90 mM NaCl to the production medium ProCHO5 increased the volumetric yield of recombinant antibody up to 4-fold rel ...

Springer Netherlands2010

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Beta amyloid and hyperphosphorylated tau deposits in the pancreas in type 2 diabetes

László Forró, Aleksandra Radenovic, Andras Kis

Strong epidemiologic evidence suggests an association between Alzheimer disease (AD) and type 2 diabetes. To determine if amyloid beta (A

\beta

) and hyperphosphorylated tau occurs in type 2 diabetes, pancreas tissues from 21 autopsy cases (10 type 2 diabe ...

Elsevier2010