Concept
Human reproduction
Related publications (13)
Human reproduction is regulated by retrotransposons derived from ancient Hominidae-specific viral infections
Didier Trono, Julien Paul André Pontis, Yu Tao
The transcription factor network required for primordial germ cell (PGC) specification is known to diverge in mammals. Here the authors show that hominidae-specific transposable element (TE) LTR5Hs becomes transcriptionally active during PGC specification, ...
NATURE PORTFOLIO2022DUX is a non-essential synchronizer of zygotic genome activation
Didier Trono, Sonia Verp, Sandra Eloise Kjeldsen, Delphine Yvette L Grun, Alberto De Iaco
Some of the earliest transcripts produced in fertilized human and mouse oocytes code for DUX, a double homeodomain protein that promotes embryonic genome activation (EGA). Deleting Dux by genome editing at the 1- to 2-cell stage in the mouse impairs EGA an ...
2019Reproductive and trans-generational effect of ocean acidification and warming on the coral Stylophora pistillata in the Gulf of Aqaba
Global warming is threatening 75 % of the world’s coral reefs. The reproduction of corals is a driver for the development of the whole reef ecosystem. Then, it is essential to better understand the transgenerational mechanisms in the response of parents an ...
2017Bidirectional Transfer Study of Polystyrene Nanoparticles across the Placental Barrier in an ex Vivo Human Placental Perfusion Model
BACKGROUND: Nanoparticle exposure in utero might not be a major concern yet, but it could become more important with the increasing application of nanomaterials in consumer and medical products. Several epidemiologic and invitro studies have shown that nan ...
Nat Inst of Environ Health Sciences / The National Institute of Environmental Health Sciences (NIEHS)2015Venus trap in the mouse embryo reveals distinct molecular dynamics underlying specification of first embryonic lineages
Didier Trono, Anna Claire Groner
Mammalian development begins with the segregation of embryonic and extra-embryonic lineages in the blastocyst. Recent studies revealed cell-to-cell gene expression heterogeneity and dynamic cell rearrangements during mouse blastocyst formation. Thus, mecha ...
2015Mechanisms of differential centriole inheritance in C. elegans
Centrosomes are the principal microtubule organizing center (MTOC) of animal cells and comprise a pair of centrioles surrounded by pericentriolar material (PCM). Centriole number must be carefully regulated to ensure bipolar spindle formation and thus fait ...
EPFL2014Quantitative Morphometrical Characterization of Human Pronuclear Zygotes
Michaël Unser, Philippe Thévenaz
BACKGROUND: Identification of embryos with high implantation potential remains a challenge in in vitro fertilization (IVF). Subjective pronuclear (PN) zygote scoring systems have been developed for that purpose. The aim of this work was to provide a softwa ...
Oxford University Press2008