Frontal lobe

Summary

The frontal lobe is the largest of the four major lobes of the brain in mammals, and is located at the front of each cerebral hemisphere (in front of the parietal lobe and the temporal lobe). It is parted from the parietal lobe by a groove between tissues called the central sulcus and from the temporal lobe by a deeper groove called the lateral sulcus (Sylvian fissure). The most anterior rounded part of the frontal lobe (though not well-defined) is known as the frontal pole, one of the three poles of the cerebrum. The frontal lobe is covered by the frontal cortex. The frontal cortex includes the premotor cortex and the primary motor cortex – parts of the motor cortex. The front part of the frontal cortex is covered by the prefrontal cortex. The nonprimary motor cortex is a functionally defined portion of the frontal lobe. There are four principal gyri in the frontal lobe. The precentral gyrus is directly anterior to the central sulcus, running parallel to it and contains the primar

Official source

https://en.wikipedia.org/wiki/Frontal_lobe

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Engineering Parallel Transmit/Receive Radio-Frequency Coil Arrays for Human Brain MRI at 7 Tesla

Jérémie Daniel Clément

Magnetic resonance imaging is widely used in medical diagnosis to obtain anatomical details of the human body in a non-invasive way. Clinical MR scanners typically operate at a static magnetic field strength (B0) of 1.5T or 3T. However, going to higher field is of great interest since the signal-to-noise ratio is proportional to B0. Therefore, higher image resolution and better contrast between the human tissues could be achieved. Nevertheless, new challenges arise when increasing B0. The wavelength associated with the radio-frequency field B1+ has smaller dimensions - approx. 12 cm for human brain tissues - than the human brain itself (20 cm in length), the organ of interest in this thesis. The main consequence is that the transmit field distribution pattern (B1+) is altered and the final MR images present bright and dark signal spots. These effects prevent the ultra-high field MR scanners (>= 7T) to be used for routine clinical diagnosis. Parallel-transmit is one approach to address these new challenges. Instead of using an RF coil connected to a single power input as it is commonly done at lower magnetic fields, multiple RF coils are used with independent power inputs. The subsequent distinct RF signals can be manipulated separately, which provides an additional degree of freedom to generate homogeneous B1+-field distributions over large or specific regions in the human body. A transmit/receive RF coil array optimized for whole-brain MR imaging was developed and is described in this thesis. Dipoles antennas were used since they could provide a large longitudinal (vertical axis-head to neck) coverage and high transmit field efficiency. Results demonstrated a complete coverage of the human brain, and particularly high homogeneity over the cerebellum. However, since the receive sensitivity over large field-of-views is related to the number of channels available to detect the NMR signal, the next work was to add a 32-channel receive loop coil array to the transmit coil array. The complete coverage of the human brain was assessed with a substantial increase in signal-to-noise compared to the transmit/receive dipole coil array alone. Moreover, acquisition time was shortened since higher acceleration factors could be used. To optimize the individual RF fields and generate an homogeneous B1+-field, a method was developed making use of the particle-swarm algorithm. A user-friendly graphical interface was implemented. Good homogeneity could be achieved over the whole-brain after optimization with the coil array built in this study. Moreover, the optimization was shown to be robust across multiple subjects. The last project was focused on the single transmit system. Local volume coils (single transmit) present pronounced transmit field inhomogeneities in specific regions of the human brain such as the temporal lobes. A widely used approach to address locally these challenges is to add dielectric pads inside the volume coils to enhance the local transmit field efficiency. It was shown in this thesis that constructing dedicated surface coils is a valuable alternative to the dielectric pads in terms of transmit field efficiency and MR spectroscopy results. Two RF coil setups were developed for the temporal and frontal lobes of the human brain, respectively. This thesis provides extensive insight on MR engineering of RF coils at ultra-high field and the potential of parallel-transmit to address the future needs in clinical applications.

EPFL2019

Voltage-sensitive dye imaging of mouse neocortex during a whisker detection task

Matthieu Pierre Auffret, Alexandros Kyriakatos, Alessandro Motta, Carl Petersen, Vijay Sadashivaiah, Yifei Zhang

Sensorimotor processing occurs in a highly distributed manner in the mammalian neocortex. The spatiotemporal dynamics of electrical activity in the dorsal mouse neocortex can be imaged using voltage-sensitive dyes (VSDs) with near-millisecond temporal resolution and similar to 100-mu m spatial resolution. Here, we trained mice to lick a water reward spout after a 1-ms deflection of the C2 whisker, and we imaged cortical dynamics during task execution with VSD RH1691. Responses to whisker deflection were highly dynamic and spatially highly distributed, exhibiting high variability from trial to trial in amplitude and spatiotemporal dynamics. We differentiated trials based on licking and whisking behavior. Hit trials, in which the mouse licked after the whisker stimulus, were accompanied by overall greater depolarization compared to miss trials, with the strongest hit versus miss differences being found in frontal cortex. Prestimulus whisking decreased behavioral performance by increasing the fraction of miss trials, and these miss trials had attenuated cortical sensorimotor responses. Our data suggest that the spatiotemporal dynamics of depolarization in mouse sensorimotor cortex evoked by a single brief whisker deflection are subject to important behavioral modulation during the execution of a simple, learned, goal-directed sensorimotor transformation. (C) The Authors. Published by SPIE under a Creative Commons Attribution 3.0 Unported License.

SPIE-Intl Soc Optical Eng2017

We review here the development of Hodgkin-Huxley (HH) type models of cerebral cortex and thalamic neurons for network simulations. The intrinsic electrophysiological properties of cortical neurons were analyzed from several preparations, and we selected the four most prominent electrophysiological classes of neurons. These four classes are "fast spiking", "regular spiking", "intrinsically bursting" and "low-threshold spike" cells. For each class, we fit "minimal" HH type models to experimental data. The models contain the minimal set of voltage-dependent currents to account for the data. To obtain models as generic as possible, we used data from different preparations in vivo and in vitro, such as rat somatosensory cortex and thalamus, guinea-pig visual and frontal cortex, ferret visual cortex, cat visual cortex and cat association cortex. For two cell classes, we used automatic fitting procedures applied to several cells, which revealed substantial cell-to-cell variability within each class. The selection of such cellular models constitutes a necessary step towards building network simulations of the thalamocortical system with realistic cellular dynamical properties.

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Engineering Parallel Transmit/Receive Radio-Frequency Coil Arrays for Human Brain MRI at 7 Tesla

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