Concept
Genistein
Related publications (20)
Upregulation of the ERR γ-VDAC1 axis underlies the molecular pathogenesis of pancreatitis
Johan Auwerx, Changmyung Oh, Jiale Wang
Emerging evidence suggest that transcription factors play multiple roles in the development of pancreatitis, a necroinflammatory condition lacking specific therapy. Estrogen-related receptor γ (ERRγ), a pleiotropic transcription factor, has been reported t ...
NATL ACAD SCIENCES2023Genistein increases the thermogenic program of subcutaneous WAT and increases energy expenditure in mice
Lilia Noriega Lopez, Laura Alejandra Velazquez Villegas
White adipose tissue (WAT) can differentiate into beige adipose tissue by the browning process. Some polyphenols, including isoflavones, particularly genistein, are suggested to increase the expression of browning markers. There is evidence that consumptio ...
ELSEVIER SCIENCE INC2019Phosphorylation of the nuclear receptor corepressor 1 by protein kinase B switches its corepressor targets in the liver in mice
Johan Auwerx, Kristina Schoonjans, Dongryeol Ryu, Xu Wang, Adriano Maida
Nuclear receptor corepressor 1 (NCoR1) is a transcriptional coregulator that has wide-ranging effects on gene expression patterns. In the liver, NCoR1 represses lipid synthesis in the fasting state, whereas it inhibits activation of peroxisome proliferator ...
Wiley-Blackwell2015Instrument intercomparison in the pulsed neutron fieldsat the CERN HiRadMat facility
Nikolaos Charitonidis, Daniel Perrin
An intercomparison of the performances of active neutron detectors was carried out in pulsed neutron fields in the new HiRadMat facility at CERN. Five detectors were employed: four of them (two ionization chambers and two rem counters) are routinely employ ...
Pergamon-Elsevier Science Ltd2014In vivo imaging reveals selective PPAR activity in the skin of peroxisome proliferator-activated receptor responsive element-luciferase reporter mice
Peroxisome proliferator-activated receptors (PPARs) have been revealed as key regulators of several skin disorders. This has led to a growing interest in the development of drugs targeting PPARs as therapeutics for skin diseases. To evaluate skin PPAR acti ...
2013Instrument intercomparison in the pulsed neutron fields at the CERN HiRadMat facility
Nikolaos Charitonidis, Daniel Perrin, Marco Silari
An intercomparison of the performances of active neutron detectors was carried out in pulsed neutron fields in the new HiRadMat facility at CERN. Five detectors were employed: four of them (two ionization chambers and two rem counters) are routinely employ ...
2013Endoplasmic Reticulum Stress Is Important for the Manifestations of alpha-Synucleinopathy In Vivo
Bernard Schneider, Ying Liu, Philippe Guillaume Coune
Accumulation of misfolded alpha-synuclein (alpha S) is mechanistically linked to neurodegeneration in Parkinson's disease (PD) and other alpha-synucleinopathies. However, how alpha S causes neurodegeneration is unresolved. Because cellular accumulation of ...
Society for Neuroscience2012Impaired myogenesis in estrogen-related receptor γ (ERRγ)-deficient skeletal myocytes due to oxidative stress
Specialized contractile function and increased mitochondrial number and oxidative capacity are hallmark features of myocyte differentiation. The estrogen-related receptors (ERRs) can regulate mitochondrial biogenesis or mitochondrial enzyme expression in s ...
Federation Amer Soc Exp Biol2012Photoactive sawhorse-type diruthenium tetracarbonyl complexes
Georges Wagnières, Frédéric Schmitt
Sawhorse-type diruthenium tetracarbonyl complexes incorporating carboxyphenyl porphyrin bridges and pyridine axial ligands have been prepared, characterized and evaluated as potential photosensitizing and chemotherapeutic agents in several human cancer cel ...
Elsevier2012