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Background: After a stroke, patients show significant modifications of neural control of movement, such as abnormal muscle co-activation, and reduced selectivity and modulation of muscle activity. Nonetheless, results reported in literature do not allow to ...
Histone deacetylase (HDAC) 4 is a transcriptional repressor that contains a glutamine-rich domain. We hypothesised that it may be involved in the molecular pathogenesis of Huntington's disease (HD), a protein-folding neurodegenerative disorder caused by an ...
Salamanders are capable of a variety of locomotor behaviors including swimming, underwater stepping, and forward and backward land stepping. According to electromyographic and kinematic recordings of the trunk, each of these behaviors is characterized by a ...
One of the major deficiencies of current robots in comparison to living beings is the ability to adapt to new conditions either resulting from environmental changes or their own dynamics. In this work we focus on situations where the robot experiences invo ...
Since GABAA-mediated intracortical inhibition has been shown to underlie plastic changes throughout the lifespan from development to aging, here, the aging motor system was used as a model to analyze the interdependence of plastic alterations within the in ...
Muscle synergies have been proposed as building blocks that simplify the construction of movements, and as a method to study motor behavior. However, the pre-processing of the EMG signals and the factorization algorithm may impact on their extraction and m ...
Gait and balance training is an essential ingredient for locomotor rehabilitation of patients with neurological impairments. Robotic overhead support systems may help these patients train, for example by relieving them of part of their body weight. However ...
Stroke is the leading cause of disabilities in the western world and may cause severe motor impairments. In the current clinical practice, progress during physical rehabilitation is assessed by a therapist for specific motor functions and through questionn ...
Complex movements require the interplay of local activation and interareal communication of sensorimotor brain regions. This is reflected in a decrease of task-related spectral power over the sensorimotor cortices and an increase in functional connectivity ...
We have found that the brainstem-spinal cord circuitry of decerebrated cats actively maintain the equilibrium during standing, walking and imposed mechanical perturbations similar to that observed in intact animals. The corrective hindlimb motor responses ...